Macrophages and T-cell apoptosis in HIV infection: a leading role for accessory cells?

被引：23

作者：

Mahlknecht, U ^{[1
]}

Herbein, G

机构：

[1] Univ Texas, Med Branch, Div Infect Dis, Galveston, TX 77555 USA

[2] Goethe Univ Frankfurt, Dept Hematol Oncol, D-6000 Frankfurt, Germany

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 05期

关键词：

D O I：

10.1016/S1471-4906(01)01898-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies indicate that macrophages modulate T-cell apoptosis in HIV infection. Macrophages have been shown to trigger apoptosis of uninfected bystander T cells and to protect HIV-infected T cells from apoptosis. This article raises the possibility that macrophages, via modulation of T-cell apoptosis, play a crucial role in both immune suppression and the-formation of viral reservoirs during HIV infection.

引用

页码：256 / 260

页数：5

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