Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder

被引：33

作者：

Scherk, H. ^{[1
]}

Backens, M. ^{[2
]}

Schneider-Axmann, T. ^{[1
]}

Kemmer, C. ^{[3
]}

Usher, J. ^{[1
]}

Reith, W. ^{[2
]}

Falkai, P. ^{[1
]}

Gruber, O. ^{[3
]}

机构：

[1] Univ Gottingen, Dept Psychiat & Psychotherapy, D-37075 Gottingen, Germany

[2] Saarland Univ Hosp, Dept Neuroradiol, Homburg, Germany

[3] Saarland Univ Hosp, Dept Psychiat & Psychotherapy, Homburg, Germany

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2008年 / 117卷 / 04期

关键词：

magnetic resonance spectroscopy; N-acetyl-aspartate; bipolar disorder; hippocampus; thalamus;

D O I：

10.1111/j.1600-0447.2007.01142.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Subcortical regions such as hippocampus, thalamus and ventral putamen are assumed to be involved in the pathophysiology of mood regulation. Disturbed hippocampal neuronal function indicated by reduced N-acetyl-aspartate (NAA) levels in bipolar patients was shown by several studies. Results in thalamus and putamen are inconsistent. Method: N-acetyl-aspartate, choline (Cho), creatine (Cr) and myo-inositol (Ins) were measured in left hippocampus, left thalamus and left putamen using proton magnetic resonance spectroscopy in 13 euthymic patients with bipolar I disorder and 13 pairwise matched healthy control subjects. Metabolic ratios NAA/Cr, NAA/Cho, Cho/Cr and Ins/Cr were calculated. Results: Patients with bipolar I disorder demonstrated significantly reduced NAA/Cr in the left hippocampus compared with healthy control subjects. No alterations were found in thalamus or putamen. Conclusion: We hypothesize that this NAA/Cr reduction might reflect neuronal dysfunction in the left hippocampus in patients with bipolar disorder.

引用

页码：283 / 288

页数：6

共 26 条

[1] Hippocampal 1H MRS in patients with bipolar disorder taking valproate versus valproate plus quetiapine [J].

Atmaca, Murad ;

Yildirim, Hanef ;

Ozdemir, Huseyin ;

Ogur, Erkin ;

Tezcan, Ertan .

PSYCHOLOGICAL MEDICINE, 2007, 37 (01) :121-129

[2] Hippocampal 1H MRS in first-episode bipolar I patients [J].

Atmaca, Murad ;

Yidirim, Hanefi ;

Ozdemir, Huseyin ;

Poyraz, A. Kursad ;

Tezcan, Ertan ;

Ogur, Erkin .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2006, 30 (07) :1235-1239

[3] Neuronal pathology in the hippocampal area of patients with bipolar disorder: A study with proton magnetic resonance spectroscopic imaging [J].

Bertolino, A ;

Frye, M ;

Callicott, JH ;

Mattay, VS ;

Rakow, R ;

Shelton-Repella, J ;

Post, R ;

Weinberger, DR .

BIOLOGICAL PSYCHIATRY, 2003, 53 (10) :906-913

[4] Hippocampal neurochemical pathology in patients at first episode of affective psychosis: a proton magnetic resonance spectroscopic imaging study [J].

Blasi, G ;

Bertolino, A ;

Brudaglio, F ;

Sciota, D ;

Altamura, M ;

Antonucci, N ;

Scarabino, T ;

Weinberger, DR ;

Nardini, M .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2004, 131 (02) :95-105

[5] 1H MRS study of dorsolateral prefrontal cortex in healthy individuals before and after lithium administration [J].

Brambilla, P ;

Stanley, JA ;

Sassi, RB ;

Nicoletti, MA ;

Mallinger, AG ;

Keshavan, MS ;

Soares, JC .

NEUROPSYCHOPHARMACOLOGY, 2004, 29 (10) :1918-1924

[6] Proton MR spectroscopy in clinical routine [J].

Burtscher, IM ;

Holtås, S .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2001, 13 (04) :560-567

[7] Long-term treatment of rats with haloperidol:: Lack of an effect on brain N-acetyl aspartate levels [J].

Bustillo, J ;

Barrow, R ;

Paz, R ;

Tang, J ;

Seraji-Bozorgzad, N ;

Moore, GJ ;

Bolognani, F ;

Lauriello, J ;

Perrone-Bizzozero, N ;

Galloway, MP .

NEUROPSYCHOPHARMACOLOGY, 2006, 31 (04) :751-756

[8] Treatment of rats with antipsychotic drugs:: lack of an effect on brain N-acetyl aspartate levels [J].

Bustillo, J ;

Wolff, C ;

Myers-y-Gutierrez, A ;

Dettmer, TS ;

Cooper, TB ;

Allan, A ;

Lauriello, J ;

Valenzuela, CF .

SCHIZOPHRENIA RESEARCH, 2004, 66 (01) :31-39

[9] Lower concentration of hippocampal N-acetylaspartate in familial bipolar I disorder [J].

Deicken, RF ;

Pegues, MP ;

Anzalone, S ;

Feiwell, R ;

Soher, B .

AMERICAN JOURNAL OF PSYCHIATRY, 2003, 160 (05) :873-882

[10] Increased thalamic N-acetylaspartate in male patients with familial bipolar I disorder [J].

Deicken, RF ;

Eliaz, Y ;

Feiwell, R ;

Schuff, N .

PSYCHIATRY RESEARCH-NEUROIMAGING, 2001, 106 (01) :35-45

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