The pituitary effects of GnRH

被引:74
作者
Pawson, AJ [1 ]
McNeilly, AS [1 ]
机构
[1] Univ Edinburgh, MRC, Human Reprod Sci Unit, Edinburgh EH16 4SB, Midlothian, Scotland
基金
英国惠康基金;
关键词
phylogeny; scaffolding; trafficking; packaging; granins;
D O I
10.1016/j.anireprosci.2005.05.010
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Advances in our understanding of the complexity of GnRH actions at the pituitary and the various mechanisms involved in mediating differential LH and FSH biosynthesis and secretion at the gonadotrope, are continually emerging. In this review, we summarise recent studies pertaining to GnRH and GnRH receptor phylogeny, the divergent signalling and trafficking pathways initiated and utilised by GnRH and its receptor, and the pathways that mediate gonadotropin secretion from the gonadotrope. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:75 / 94
页数:20
相关论文
共 114 条
[1]  
Acharjee S, 2002, MOL CELLS, V14, P101
[2]   The caveolae membrane system [J].
Anderson, RGW .
ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :199-225
[3]   DECAY OF FOLLICLE-STIMULATING HORMONE-BETA MESSENGER-RNA IN THE PRESENCE OF TRANSCRIPTIONAL INHIBITORS AND OR INHIBIN, ACTIVIN, OR FOLLISTATIN [J].
ATTARDI, B ;
WINTERS, SJ .
MOLECULAR ENDOCRINOLOGY, 1993, 7 (05) :668-680
[4]   RELATIONSHIP BETWEEN LH, FSH, AND PROLACTIN CONCENTRATION AND THE SECRETION OF ANDROGENS AND ESTROGENS BY THE PREOVULATORY FOLLICLE IN THE EWE [J].
BAIRD, DT ;
SWANSTON, IA ;
MCNEILLY, AS .
BIOLOGY OF REPRODUCTION, 1981, 24 (05) :1013-1025
[5]   Minireview: Inhibin binding protein (InhBP/p120), betaglycan, and the continuing search for the inhibin receptor [J].
Bernard, DJ ;
Chapman, SC ;
Woodruff, TK .
MOLECULAR ENDOCRINOLOGY, 2002, 16 (02) :207-212
[6]   Pivotal role for the cytoplasmic carboxyl-terminal tail of a nonmammalian gonadotropin-releasing hormone receptor in cell surface expression, ligand binding, and receptor phosphorylation and internalization [J].
Blomenröhr, M ;
Heding, A ;
Sellar, R ;
Leurs, R ;
Bogerd, J ;
Eidne, KA ;
Willars, GB .
MOLECULAR PHARMACOLOGY, 1999, 56 (06) :1229-1237
[7]   Differences in structure-function relations between nonmammalian and mammalian gonadotropin-releasing hormone receptors [J].
Blomenrohr, M ;
Bogerd, J ;
Leurs, R ;
Schulz, RW ;
Tensen, CP ;
Zandbergen, MA ;
Goos, HJT .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 238 (02) :517-522
[8]  
BLOMQUIST JF, 1992, J BIOL CHEM, V267, P20798
[9]   RELATIONSHIP BETWEEN GONADOTROPIN SUBUNIT GENE-EXPRESSION, GONADOTROPIN-RELEASING-HORMONE RECEPTOR CONTENT AND PITUITARY AND PLASMA GONADOTROPIN CONCENTRATIONS DURING THE REBOUND RELEASE OF FSH AFTER TREATMENT OF EWES WITH BOVINE FOLLICULAR-FLUID DURING THE LUTEAL PHASE OF THE CYCLE [J].
BROOKS, J ;
CROW, WJ ;
MCNEILLY, JR ;
MCNEILLY, AS .
JOURNAL OF MOLECULAR ENDOCRINOLOGY, 1992, 8 (02) :109-118
[10]   Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization [J].
Brothers, SP ;
Janovick, JA ;
Maya-Nunez, G ;
Cornea, A ;
Han, XB ;
Conn, PM .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2002, 190 (1-2) :19-27