Evidence for galanin receptors in primary sensory neurones and effect of axotomy and inflammation

被引：87

作者：

Xu, ZQ ^{[1
]}

Shi, TJ ^{[1
]}

Landry, M ^{[1
]}

Hokfelt, T ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT NEUROSCI,S-17177 STOCKHOLM,SWEDEN

来源：

NEUROREPORT | 1996年 / 8卷 / 01期

关键词：

autoreceptors; dorsal root ganglion; nerve injury; neuropeptide; pain;

D O I：

10.1097/00001756-199612200-00048

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

USING in situ hybridization, mRNA coding for the galanin R1 receptor (GAL-R1) was demonstrated in > 20% of all lumbar 4 and 5 dorsal root ganglion neurone profiles, mainly constituting small and medium sized neurones. Almost all of these neurones expressed CGRP mRNA as revealed by analysis of adjacent sections and of the same section using a double-labelling technique. GAL-R1 mRNA levels were down-regulated transiently by inflammation, and more strongly by peripheral nerve injury. These results suggest that DRG neurones are sensitive to galanin and that GAL-R1 receptors are involved in sensory processing.

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收藏

页码：237 / 242

页数：6

相关论文

共 34 条

[1]

AHMAD S, 1996, 8 WORLD C PAIN VANC, P134

[2] EXPRESSION BRAIN OF A MESSENGER-RNA ENCODING A NOVEL NEUROPEPTIDE HOMOLOGOUS TO CALCITONIN GENE-RELATED PEPTIDE [J].

AMARA, SG ;

ARRIZA, JL ;

LEFF, SE ;

SWANSON, LW ;

EVANS, RM ;

ROSENFELD, MG .

SCIENCE, 1985, 229 (4718) :1094-1097

[3]

BURGEVIN MC, 1995, J MOL NEUROSCI, V6

[4] DISTRIBUTION OF GALANIN IMMUNOREACTIVITY IN THE CENTRAL NERVOUS-SYSTEM AND THE RESPONSES OF GALANIN-CONTAINING NEURONAL PATHWAYS TO INJURY [J].

CHNG, JLC ;

CHRISTOFIDES, ND ;

ANAND, P ;

GIBSON, SJ ;

ALLEN, YS ;

SU, HC ;

TATEMOTO, K ;

MORRISON, JFB ;

POLAK, JM ;

BLOOM, SR .

NEUROSCIENCE, 1985, 16 (02) :343-354

[5] EFFECTS OF INTRATHECAL ADMINISTRATION OF NEUROPEPTIDES ON A SPINAL NOCICEPTIVE REFLEX IN THE RAT - VIP, GALANIN, CGRP, TRH, SOMATOSTATIN AND ANGIOTENSIN-II [J].

CRIDLAND, RA ;

HENRY, JL .

NEUROPEPTIDES, 1988, 11 (01) :23-32

[6] SENSITIVE MESSENGER-RNA DETECTION USING UNFIXED TISSUE - COMBINED RADIOACTIVE AND NONRADIOACTIVE INSITU HYBRIDIZATION HISTOCHEMISTRY [J].

DAGERLIND, A ;

FRIBERG, K ;

BEAN, AJ ;

HOKFELT, T .

HISTOCHEMISTRY, 1992, 98 (01) :39-49

[7] MOLECULAR-CLONING OF A FUNCTIONAL HUMAN GALANIN RECEPTOR [J].

HABERTORTOLI, E ;

AMIRANOFF, B ;

LOQUET, I ;

LABURTHE, M ;

MAYAUX, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :9780-9783

[8] INCREASE OF GALANIN-LIKE IMMUNOREACTIVITY IN RAT DORSAL-ROOT GANGLION-CELLS AFTER PERIPHERAL AXOTOMY [J].

HOKFELT, T ;

WIESENFELDHALLIN, Z ;

VILLAR, M ;

MELANDER, T .

NEUROSCIENCE LETTERS, 1987, 83 (03) :217-220

[9]

HOKFELT T, 1991, GALANIN NEW MULTIFUN

[10] GALANIN RECEPTOR-BINDING SITES IN ADULT-RAT SPINAL-CORD RESPOND DIFFERENTIALLY TO NEONATAL CAPSAICIN, DORSAL RHIZOTOMY AND PERIPHERAL AXOTOMY [J].

KAR, S ;

QUIRION, R .

EUROPEAN JOURNAL OF NEUROSCIENCE, 1994, 6 (12) :1917-1921

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