A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men

被引:166
作者
Watzl, B [1 ]
Kulling, SE [1 ]
Möseneder, J [1 ]
Barth, SW [1 ]
Bub, A [1 ]
机构
[1] Fed Res Ctr Nutr & Food, Inst Nutr Physiol, D-76131 Karlsruhe, Germany
关键词
vegetables; fruit; natural killer cells; cytokines; C-reactive protein;
D O I
10.1093/ajcn/82.5.1052
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Whether different intakes of vegetables and fruit modulate immunologic markers is currently not known. Objective: We investigated the effects of low, medium, and high intakes of vegetables and fruit on markers of immune functions, including nonspecific markers of inflammation. Design: In a randomized controlled trial, nonsmoking men consumed a diet that included :52 servings/d of vegetables and fruit for 4 wk. The subjects were then randomly assigned to 1 of 3 groups to consume 2 servings/d, 5 servings/d, or 8 servings/d of carotenoid-rich vegetables and fruit for another 4-wk period. Plasma concentrations of vitamins C and E and carotenoids were measured. The assessment of immunologic and inflammatory markers included the number and activity of natural killer cells, secretion of cytokines, lymphocyte proliferation, and plasma C-reactive protein concentrations. Results: The high intake (8 servings/d) of vegetables and fruit significantly increased total carotenoid concentrations in plasma compared with the low intake (2 servings/d; week 4 compared with week 8), whereas concentrations of vitamins C and E did not differ between week 4 and week 8. Immunologic markers were not significantly modulated. In contrast, C-reactive protein was significantly reduced at week 8 in the subjects who consumed 8 servings/d of vegetables and fruit compared with those who consumed 2 servings/d. Conclusions: In healthy, well-nourished, nonsmoking men, 4 wk of low or high intakes of carotenoid-rich vegetables and fruit did not affect markers of immune function. However, a high intake of vegetables and fruit may reduce inflammatory processes, as indicated by the reduction of plasma C-reactive protein.
引用
收藏
页码:1052 / 1058
页数:7
相关论文
共 39 条
[1]   Consumption of vegetables, fruit and other plant foods in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohorts from 10 European countries [J].
Agudo, A ;
Slimani, N ;
Ocké, MC ;
Naska, A ;
Miller, AB ;
Kroke, A ;
Bamia, C ;
Karalis, D ;
Vineis, P ;
Palli, D ;
Bueno-de-Mesquita, HB ;
Peeters, PHM ;
Engeset, D ;
Hjartåker, A ;
Navarro, C ;
Garcia, CM ;
Wallström, P ;
Zhang, JX ;
Welch, AA ;
Spencer, E ;
Stripp, C ;
Overvad, K ;
Clavel-Chapelon, F ;
Casagrande, C ;
Riboli, E .
PUBLIC HEALTH NUTRITION, 2002, 5 (6B) :1179-1196
[2]   Dietary fiber and C-reactive protein: Findings from National Health and Nutrition Examination Survey Data [J].
Ajani, UA ;
Ford, ES ;
Mokdad, AH .
JOURNAL OF NUTRITION, 2004, 134 (05) :1181-1185
[3]   High-sensitivity C-reactive protein: Clinical importance [J].
Bassuk, SS ;
Rifai, N ;
Ridker, PM .
CURRENT PROBLEMS IN CARDIOLOGY, 2004, 29 (08) :439-493
[4]  
Beecher GR, 1998, P SOC EXP BIOL MED, V218, P98, DOI 10.3181/00379727-218-44282a
[5]   Activation and function of natural killer cell responses during viral infections [J].
Biron, CA .
CURRENT OPINION IN IMMUNOLOGY, 1997, 9 (01) :24-34
[6]   The relative validity of vitamin intakes derived from a food frequency questionnaire compared to 24-hour recalls and biological measurements: Results from the EPIC pilot study in Germany [J].
Boeing, H ;
BohlscheidThomas, S ;
Voss, S ;
Schneeweiss, S ;
Wahrendorf, J .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1997, 26 :S82-S90
[7]   Six carotenoids in plasma used to assess recommended intake of fruits and vegetables in a controlled feeding study [J].
Brevik, A ;
Andersen, LF ;
Karlsen, A ;
Trygg, KU ;
Blomhoff, R ;
Drevon, CA .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2004, 58 (08) :1166-1173
[8]   Effects of supplementing a low-carotenoid diet with a tomato extract for 2 weeks on endogenous levels of DNA single strand breaks and immune functions in healthy non-smokers and smokers [J].
Briviba, K ;
Kulling, SE ;
Möseneder, J ;
Watzl, B ;
Rechkemmer, G ;
Bub, A .
CARCINOGENESIS, 2004, 25 (12) :2373-2378
[9]  
CHANG L, 1993, J IMMUNOL METHODS, V166, P45
[10]   The biology of human natural killer-cell subsets [J].
Cooper, MA ;
Fehniger, TA ;
Caligiuri, MA .
TRENDS IN IMMUNOLOGY, 2001, 22 (11) :633-640