A new decoration for nitric oxide synthase -: a Zn(Cys)4 site

被引：30

作者：

Ludwig, ML ^{[1
]}

Marletta, MA

机构：

[1] Univ Michigan, Div Biophys Res, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Biol Chem, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA

来源：

STRUCTURE | 1999年 / 7卷 / 04期

关键词：

D O I：

10.1016/S0969-2126(99)80047-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Intense interest in the action and synthesis of nitric oxide has fuelled structural studies of nitric oxide synthase (NOS). The monomeric and dimeric heme domains of inducible NOS were the first NOS structures to be described. A recent independent analysis of the corresponding heme domains from endothelial NOS confirms most of the features found earlier and also reveals a novel Zn(Cys)(4) center - a new feature far NOS.

引用

页码：R73 / R79

页数：7

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