共 53 条
CD26-processed RANTES(3-68), but not intact RANTES, has potent anti-HIV-1 activity
被引:64
作者:

Schols, D
论文数: 0 引用数: 0
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机构: Rega Inst Med Res, Lab Expt Chemotherapy, B-3000 Louvain, Belgium

Proost, P
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机构: Rega Inst Med Res, Lab Expt Chemotherapy, B-3000 Louvain, Belgium

Struyf, S
论文数: 0 引用数: 0
h-index: 0
机构: Rega Inst Med Res, Lab Expt Chemotherapy, B-3000 Louvain, Belgium

Wuyts, A
论文数: 0 引用数: 0
h-index: 0
机构: Rega Inst Med Res, Lab Expt Chemotherapy, B-3000 Louvain, Belgium

De Meester, I
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机构: Rega Inst Med Res, Lab Expt Chemotherapy, B-3000 Louvain, Belgium

Scharpé, S
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h-index: 0
机构: Rega Inst Med Res, Lab Expt Chemotherapy, B-3000 Louvain, Belgium

Van Damme, J
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h-index: 0
机构: Rega Inst Med Res, Lab Expt Chemotherapy, B-3000 Louvain, Belgium

De Clercq, E
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h-index: 0
机构: Rega Inst Med Res, Lab Expt Chemotherapy, B-3000 Louvain, Belgium
机构:
[1] Rega Inst Med Res, Lab Expt Chemotherapy, B-3000 Louvain, Belgium
[2] Rega Inst Med Res, Lab Mol Immunol, B-3000 Louvain, Belgium
[3] Univ Antwerp, Dept Clin Biochem, B-2610 Wilrijk, Belgium
关键词:
CD26;
RANTES;
anti-HIV-1;
activity;
CCR5;
D O I:
10.1016/S0166-3542(98)00039-4
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
The natural CC-chemokine RANTES(3-68), missing two NH2-terminal residues, has been isolated from leukocytes and tumor cells, The highly specific aminopeptidase dipeptidyl peptidase IV (DPP IV), also called CD26, was shown to be responsible for this NH2-terminal truncation of RANTES. Here it is reported that CD26/DPP IV treatment of RANTES enhances its anti-HIV-1 activity. RANTES(3-68) inhibited infection of PBMC by M-tropic HIV-1 strains ten-fold more efficiently than intact RANTES, This difference in antiviral potency between intact and truncated RANTES was even more pronounced (at least 25-fold) in CCR5-transfected cell lines. In HOS.CD4.CCR5 transfected cells, RANTES(1-68) had virtually no anti-HIV-1 activity (IC50 > 130 nM), whereas RANTES(3-68) was a potent inhibitor of HIV-1 replication (IC50: 5.5 nM). The anti-HIV-1 activity of RANTES(1-68) in the different cell types correlated with the expression of CD26, Moreover, the addition of soluble CD26 together with RANTES(1-68) significantly enhanced the antiviral activity of RANTES in HOS.CD4.CCR5 cells (IC50: 13 nM). These observations point to an important role of CD26-mediated processing of RANTES in inhibiting the replication of CCR5-binding HIV strains in HIV-infected persons and in preventing the development of AIDS. (C) 1998 Elsevier Science B.V. All rights reserved.
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页码:175 / 187
页数:13
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