Efficient synthesis of chiral α- and β-hydroxy amides:: Application to the synthesis of (R)-fluoxetine

被引：84

作者：

Kakei, H ^{[1
]}

Nemoto, T ^{[1
]}

Ohshima, T ^{[1
]}

Shibasaki, M ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 03期

关键词：

asymmetric synthesis; epoxides; regioselectivity; synthetic methods;

D O I：

10.1002/anie.200352431

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four flavors for epoxide openings: The regioselective openings of epoxy amides obtained by asymmetric epoxidation yields all types of aryl- and alkyl-substituted hydroxy amides sometimes counter to the reactivity of the α- and β-positions.

引用

页码：317 / 320

页数：4

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