Immobile plasticizer in flexible PVC

被引：38

作者：

Jayakrishnan, K ^{[1
]}

Lakshmi, S ^{[1
]}

机构：

[1] Sree Chitra Tirunal Inst Med Sci & Technol, Biomed Technol Wing, Div Polymer Chem, Trivandrum 695012, Kerala, India

来源：

NATURE | 1998年 / 396卷 / 6712期

关键词：

D O I：

10.1038/25275

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Plasticized poly(vinyl chloride) (PVC) is one of the most widely used polymeric materials in medical and related applications, and usually contains up to 40 per cent di-(2-ethylhexyl)phthalate (DEHP), which acts as the ‘plasticizer’ to impart flexibility to an otherwise rigid PVC1. The plasticizer can migrate from PVC-based devices and storage bags into physiological fluids, however, and has been detected in storage media such as blood, plasma, serum, drug solutions and fatty foods2,3,4, as well as in the bodies of patients undergoing haemodialysis and transfusion5. This is a concern because DEHP is a lipid-removing liver carcinogen6, and causes hepatic7 and reproductive toxicity8 in rodents, although opinion is divided on its toxicity in humans9.

引用

页码：638 / 638

页数：1

共 12 条

[1] BIOMATERIALS FOR BLOOD TUBING - THE APPLICATION OF PLASTICIZED POLY(VINYL CHLORIDE) [J].