V1a receptor knockout mice exhibit impairment of spatial memory in an eight-arm radial maze

in this study, we examined the performance of vasopressin V1a receptor (V1aR) and vasopressin V1b receptor (V1bR) knockout (KO) mice compared to wild-type (WT) mice in an eight-ann radial maze. V1aR KO mice exhibited an impairment of spatial memory in comparison to WT mice. By contrast, we did not observe any significant differences between the V1bR KO mice and the WT mice in the eight-arm radial maze. Moreover, OPC-21268, a selective V1aR antagonist, impaired spatial memory in the eight-ann radial maze in WT mice characterized by an increased number of errors. These results suggest that the V1aR controls spatial memory in mice. (C) 2003 Elsevier Ireland Ltd. All rights reserved.