Paraoxonase-1 in chronic liver diseases, neurological diseases and HIV infection

被引：17

作者：

Marsillach, J. ^{[1
]}

Parra, S. ^{[1
]}

Ferre, N. ^{[2
]}

Coll, B. ^{[1
]}

Alonso-Villaverde, C. ^{[1
]}

Joven, J. ^{[1
]}

Camps, J. ^{[1
]}

机构：

[1] Hosp Univ St Joan, Ctr Recerca Biomed, Inst Recerca Ciencies Salut, Dept Internal Med, C St Joan S-N, Reus 43201, Catalunya, Spain

[2] Hosp Clin Barcelona, Dept Clin Biochem & Mol Genet, Barcelona, Spain

来源：

PARAOXNASES: THEIR ROLE IN DISEASE DEVELOPMENT AND XENOBIOTIC METABOLISM | 2008年 / 6卷

关键词：

HIV infection; chronic liver diseases; neurological diseases; oxidative stress; paraoxonase-1;

D O I：

10.1007/978-1-4020-6561-3_12

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Over recent years there has been a rapid increase in the number of articles reporting paraoxonase-1 (PON1) alterations in diseases other than arteriosclerosis, and which involve an increased degree of oxidative stress. Chronic liver impairment is associated with decreased serum PON1 activity but with increased serum PON1 concentration; this unusual juxtaposition being explained, perhaps, by the molecular alterations related to collagen synthesis and to the inactivation of the enzyme's active site by lipid peroxides. Polymorphisms of the PON1 gene have been shown to be associated with an increased development of several neurological diseases and to influence the organism's capacity to protect against neurotoxins. Many infectious diseases, as HIV infection, produce a high oxidative stress, and alterations in PON1 activity and concentration may be related to the course of the disease.

引用

页码：187 / +

页数：6

共 80 条

[1]

Paraoxonase 1 Met-Leu 54 polymorphism is associated with Parkinson's disease [J].