Endometrial secretions: creating a stimulatory microenvironment within the human early placenta and implications for the aetiopathogenesis of preeclampsia

被引:70
作者
Burton, G. J. [2 ]
Scioscia, M. [3 ]
Rademacher, T. W. [1 ,4 ]
机构
[1] Univ Oxford, Ctr Innovat & Enterprise, Yarnton OX5 1PF, England
[2] Ctr Trophoblast Res, Dept Physiol Neurosci & Dev, Physiol Lab, Cambridge CBE 3EG, England
[3] Sacro Cuore Don Calabria, Dept Obstet & Gynaecol, Verona, Italy
[4] UCL, Div Infect & Immun, London W1T 4JF, England
关键词
Pre-eclampsia; Endometrial secretions; Insulin; IPGs; INOSITOL PHOSPHOGLYCAN-P; MATERNAL-FETAL RELATION; EPIDERMAL-GROWTH-FACTOR; AMNIOTIC-FLUID; 1ST TRIMESTER; TRANSPLANTATION IMMUNITY; ENDOTHELIAL GLYCOCALYX; RHEUMATOID-ARTHRITIS; INSULIN-RESISTANCE; GESTATIONAL-AGE;
D O I
10.1016/j.jri.2011.02.005
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
Endometrial glands represent an important source of nutrients for the conceptus during the first trimester. Their secretions are enriched with carbohydrates, and glycogen accumulates within the syncytiotrophoblast of the placenta. It has been assumed that fetal and placental metabolism follow adult pathways, although it is now appreciated that early development occurs in a low-oxygen environment. In past decades, a novel family of putative insulin mediators, inositol phosphoglycans (IPGs), was discovered. These molecules act as allosteric activators and/or inhibitors of enzymes and transduction proteins involved in the control of cell signalling and metabolic pathways, and determine the specificity of responses after activation of the insulin receptor. One member, IPG P-type, activates pyruvate dehydrogenase phosphatase (PDH-Pase), glycogen synthase phosphatase, and glycerol-3-phosphate acyltransferase. Activation of key phosphatases play a major role in the regulation of glucose disposal by oxidative metabolism via PDH, and the non-oxidative storage by glycogen synthesis, both pathways classically known to be regulated by insulin. High concentrations of IPG P-type in amniotic fluid suggest a role in the regulation of carbohydrate metabolism in the fetal-placental unit. Glycogen accumulation in the syncytiotrophoblast also occurs in preeclamptic pregnancies, and is consistently associated with higher placental levels of IPG P-type. Here, we explore the relationship between nutrients provided by the endometrial glands during early pregnancy, IPG P-type and fetal metabolic requirements. We also discuss whether a disconnect between the placental/fetal metabolic state and oxygen tension could lead to a preeclamptic-type syndrome via leakage of Warburg/IPG mediators into the maternal circulation. (C) 2011 Published by Elsevier Ireland Ltd.
引用
收藏
页码:118 / 125
页数:8
相关论文
共 80 条
[1]
Oncotic pressures opposing filtration across non-fenestrated rat microvessels [J].
Adamson, RH ;
Lenz, JE ;
Zhang, X ;
Adamson, GN ;
Weinbaum, S ;
Curry, FE .
JOURNAL OF PHYSIOLOGY-LONDON, 2004, 557 (03) :889-907
[2]
SYNCYTIOTROPHOBLAST MEMBRANE-PROTEIN GLYCOSYLATION PATTERNS IN NORMAL HUMAN-PREGNANCY AND CHANGES WITH GESTATIONAL-AGE AND PARTURITION [J].
ARKWRIGHT, PD ;
REDMAN, CWG ;
WILLIAMS, PJ ;
DWEK, RA ;
RADEMACHER, TW .
PLACENTA, 1991, 12 (06) :637-651
[3]
PREECLAMPSIA IS ASSOCIATED WITH AN INCREASE IN TROPHOBLAST GLYCOGEN-CONTENT AND GLYCOGEN-SYNTHASE ACTIVITY, SIMILAR TO THAT FOUND IN HYDATIDIFORM MOLES [J].
ARKWRIGHT, PD ;
RADEMACHER, TW ;
DWEK, RA ;
REDMAN, CWG .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (06) :2744-2753
[4]
Predictors of neonatal outcome in early-onset placental dysfunction [J].
Baschat, Ahmet A. ;
Cosmi, Erich ;
Bilardo, Catarina M. ;
Wolf, Hans ;
Berg, Christoph ;
Rigano, Serena ;
Germer, Ute ;
Moyano, Dolores ;
Turan, Sifa ;
Hartung, John ;
Bhide, Amarnath ;
Muller, Thomas ;
Bower, Sarah ;
Nicolaides, Kypros H. ;
Thilaganathan, Baskaran ;
Gembruch, Ulrich ;
Ferrazzi, Enrico ;
Hecher, Kurt ;
Galan, Henry L. ;
Harman, Chris R. .
OBSTETRICS AND GYNECOLOGY, 2007, 109 (02) :253-261
[5]
BEIRHELLWIG K, 1989, HUM REPROD S, V4, P115
[6]
Bell S C, 1988, J Reprod Fertil Suppl, V36, P109
[7]
BERNARD M, 2003, CIRC RES, V92, P592
[8]
TRANSPLANTATION IMMUNITY + MATERNAL-FETAL RELATION ( CONCLUDED) [J].
BILLINGHAM, RE .
NEW ENGLAND JOURNAL OF MEDICINE, 1964, 270 (14) :720-+
[9]
TRANSPLANTATION IMMUNITY + MATERNAL-FETAL RELATION [J].
BILLINGHAM, RE .
NEW ENGLAND JOURNAL OF MEDICINE, 1964, 270 (13) :667-&
[10]
Ovarian stimulation for in vitro fertilization alters the intrauterine cytokine, chemokine, and growth factor milieu encountered by the embryo [J].
Boomsma, Carolien M. ;
Kavelaars, Annemieke ;
Eijkemans, Marinus J. C. ;
Fauser, Bart C. J. M. ;
Heijnen, Cobi J. ;
Macklon, Nick S. .
FERTILITY AND STERILITY, 2010, 94 (05) :1764-1768