Straightforward synthesis of N-protected benzylic amines by carbamoalkylation of aromatic compounds

被引：14

作者：

Bensel, N

Pevere, V

Desmurs, JR

Wagner, A

Mioskowski, C

机构：

[1] Univ Strasbourg 1, Lab Synthese Bioorgan, UMR 7514, Fac Pharm, F-67400 Illkirch Graffenstaden, France

[2] Rhodia Organ Fine, CRIT Decine, F-69153 Decine Charpieu, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(98)02578-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A wide range of alkoxycarbonyl protected benzylic amines have been synthesized in a three component reaction involving a carbamate an aldehyde and an aromatic substrate, This reaction proceeds through electrophilic substitution of the aromatic compound by a N-carbamoyl iminium which is generated in situ by condensation of the carbamate with the aldehyde. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：879 / 882

页数：4

共 5 条

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