Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus

被引：468

作者：

Murrell, Dedee E. ^{[2
]}

Dick, Sarah ^{[1
]}

Ahmed, A. R. ^{[23
]}

Amagai, Masayuki ^{[3
]}

Barnadas, Maria A. ^{[4
]}

Borradori, Luca ^{[5
]}

Bystryn, Jean-Claude ^{[6
]}

Cianchini, Giuseppe ^{[24
]}

Diaz, Luis ^{[7
]}

Fivenson, David

Hall, Russell ^{[8
]}

Harman, Karen E. ^{[9
]}

Hashimoto, Takashi ^{[10
,11
,12
]}

Hertl, Michael

Hunzelmann, Nico ^{[13
]}

Iranzo, Pilar ^{[14
]}

Joly, Pascal ^{[25
]}

Jonkman, Marcel E. ^{[15
]}

Kitajima, Yasuo ^{[16
]}

Korman, Neil J. ^{[17
]}

Martin, Linda K. ^{[2
]}

Mimouni, Daniel ^{[18
]}

Pandya, Amit G. ^{[19
]}

Payne, Aimee S. ^{[1
]}

Rubenstein, David

Shimizu, Hiroshi ^{[20
]}

Sinha, Animesh A. ^{[26
]}

Sirois, David ^{[27
]}

Zillikens, Detlef ^{[21
]}

Werth, Victoria P. ^{[1
,22
]}

机构：

[1] Univ Penn, Dept Dermatol, Philadelphia, PA 19119 USA

[2] Univ New S Wales, St Georges Hosp, Dept Dermatol, Sydney, NSW, Australia

[3] Keio Univ, Sch Med, Tokyo, Japan

[4] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[5] Univ Geneva, Hop Cantonal, CH-1211 Geneva, Switzerland

[6] NYU, Med Ctr, New York, NY 10016 USA

[7] Univ N Carolina, Chapel Hill, NC USA

[8] Duke Univ, Med Ctr, Div Dermatol, Durham, NC 27710 USA

[9] Univ Hosp Leicester, Leicester, Leics, England

[10] Kurume Univ, Sch Med, Kurume, Fukuoka, Japan

[11] Univ Giessen Klinikum, Giessen, Germany

[12] Marburg GmbH, Marburg, Germany

[13] Univ Klin Koln, Cologne, Germany

[14] Univ Barcelona, Hosp Clin, E-08007 Barcelona, Spain

[15] Univ Groningen, Univ Med Ctr Groningen, NL-9700 AB Groningen, Netherlands

[16] Gifu Univ, Sch Med, Gifu, Japan

[17] Univ Hosp, Case Med Ctr Cleveland, Cleveland, OH USA

[18] Rabin Med Ctr, Petah Tiqwa, Israel

[19] Univ Texas SW Med Ctr Dallas, Dallas, TX 75390 USA

[20] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan

[21] Med Univ Lubeck, D-23538 Lubeck, Germany

[22] Vet Affairs Med Ctr, Philadelphia Dept, Philadelphia, PA USA

[23] New England Baptist Hosp, Ctr Blistering Dis, Dept Med, Boston, MA USA

[24] IRCCS, Inst Dermopact Immacolata, Immunodermatol Dept, Rome, Italy

[25] Hop Charles Nicolle, Dermatol Clin, Rouen, France

[26] Michigan State Univ, Ctr Invest Dermatol, Div Dermatol & Cutaneous Sci, E Lansing, MI 48824 USA

[27] NYU, Dept Oral Med, New York, NY 10003 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2008年 / 58卷 / 06期

关键词：

D O I：

10.1016/j.jaad.2008.01.012

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 [皮肤病与性病学];

摘要：

Our scientific knowledge of pemphigus has dramatically progressed in recent years. However, despite the availability of various therapeutic options for the treatment of inflammatory diseases, only a few multicenter controlled trials have helped to define effective therapies in pemphigus. A major obstacle in comparing therapeutic outcomes between centers is the lack of generally accepted definitions and measurements for the clinical evaluation of patients with pemphigus. Common terms and end points of pemphigus are needed so that experts in the field can accurately measure and assess disease extent, activity, severity, and therapeutic response, and thus facilitate and advance clinical trials. This consensus statement from the International Pemphigus Committee represents 2 years of collaborative efforts to attain mutually acceptable common definitions for pemphigus. These should assist in development of consistent reporting of outcomes in future studies.

引用

页码：1043 / 1046

页数：4