Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Equation Pronouncedly Underestimates Glomerular Filtration Rate in Type 2 Diabetes

被引：94

作者：

Silveiro, Sandra P. ^{[1
,2
]}

Araujo, Gustavo N. ^{[1
]}

Ferreira, Mariana N. ^{[1
]}

Souza, Fabiola D. S. ^{[1
]}

Yamaguchi, Halley M. ^{[1
]}

Camargo, Eduardo G. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Grad Program Med Sci Endocrinol, BR-90046900 Porto Alegre, RS, Brazil

[2] Hosp Clin Porto Alegre, Endocrinol Div, Porto Alegre, RS, Brazil

来源：

DIABETES CARE | 2011年 / 34卷 / 11期

关键词：

D O I：

10.2337/dc11-1282

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-To evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation to estimate glomerular filtration rate (GFR) in type 2 diabetic patients with GFR >60 mL/min/1.73 m(2). RESEARCH DESIGN AND METHODS-This was a cross-sectional study including 105 type 2 diabetic patients. GFR was measured by Cr-51-EDTA method and estimated by the MDRD and CKD-EPI equations. Serum creatinine was measured by the traceable Jaffe method. Bland-Altman plots were used. Bias, accuracy (P30), and precision were evaluated. RESULTS-The mean age of patients was 57 +/- 8 years; 53 (50%) were men and 90 (86%) were white. Forty-six (44%) patients had microalbuminuria, and 14 (13%) had macroalbuminuria. Cr-51-EDTA GFR was 103 +/- 23, CKD-EPI GER was 83 +/- 15, and MDRD-GFR was 78 +/- 17 mL/min/1.73 m(2) (P < 0.00.1). Accuracy (95% CI) was 67% (58-74) for CKD-EPI and 64% (56-75) for MDRD. Precision was 21. and 22, respectively. CONCLUSIONS-The CKD-EPI and MDRD equations pronouncedly underestimated GER in type 2 diabetic patients.

引用

页码：2353 / 2355

页数：3

共 10 条

[1]

Amer Diabet Assoc, 2011, DIABETES CARE, V34, pS11, DOI [10.2337/dc10-S062, 10.2337/dc14-S081, 10.2337/dc11-S011, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc10-S011, 10.2337/dc12-s011]

[2]

Bland JM, 1999, STAT METHODS MED RES, V8, P135, DOI 10.1177/096228029900800204

[3]

Bland M., 2004, SAMPLE SIZE STUDY AG

[4] The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation is less accurate in patients with Type 2 diabetes when compared with healthy individuals [J].