The Path from β-Carotene to Carlactone, a Strigolactone-Like Plant Hormone

被引：710

作者：

Alder, Adrian ^{[1
]}

Jamil, Muhammad ^{[2
]}

Marzorati, Mattia ^{[3
]}

Bruno, Mark ^{[1
]}

Vermathen, Martina ^{[3
]}

Bigler, Peter ^{[3
]}

Ghisla, Sandro ^{[4
]}

Bouwmeester, Harro ^{[2
,5
]}

Beyer, Peter ^{[1
,6
]}

Al-Babili, Salim ^{[1
,6
]}

机构：

[1] Univ Freiburg, Fac Biol, D-79104 Freiburg, Germany

[2] Wageningen Univ, Lab Plant Physiol, NL-6700 AR Wageningen, Netherlands

[3] Univ Bern, Dept Chem & Biochem, CH-3012 Bern, Switzerland

[4] Univ Konstanz, Dept Biol, D-78457 Constance, Germany

[5] Ctr Biosyst Genom, NL-6700 AR Wageningen, Netherlands

[6] Ctr Biol Signalling Studies Bioss, D-79104 Freiburg, Germany

来源：

SCIENCE | 2012年 / 335卷 / 6074期

关键词：

CLEAVAGE OXYGENASES; BIOSYNTHESIS; GERMINATION; STRIGA; INHIBITION; METABOLISM; OROBANCHE; CATALYZE; ENZYMES;

D O I：

10.1126/science.1218094

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Strigolactones, phytohormones with diverse signaling activities, have a common structure consisting of two lactones connected by an enol-ether bridge. Strigolactones derive from carotenoids via a pathway involving the carotenoid cleavage dioxygenases 7 and 8 (CCD7 and CCD8) and the iron-binding protein D27. We show that D27 is a beta-carotene isomerase that converts all-trans-beta-carotene into 9-cis-beta-carotene, which is cleaved by CCD7 into a 9-cis-configured aldehyde. CCD8 incorporates three oxygens into 9-cis-beta-apo-10'-carotenal and performs molecular rearrangement, linking carotenoids with strigolactones and producing carlactone, a compound with strigolactone-like biological activities. Knowledge of the structure of carlactone will be crucial for understanding the biology of strigolactones and may have applications in combating parasitic weeds.

引用

页码：1348 / 1351

页数：4

共 32 条

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*ADV CHEM DEV INC, 2008, ACD SHIFT PRED SOFTW

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