Coordinated Increase in Serum Platelet-Derived Growth Factor-BB and Transforming Growth Factor-β1 in Patients with Chronic Pancreatitis

被引：15

作者：

Adrych, Krystian ^{[2
]}

Smoczynski, Marian ^{[2
]}

Stojek, Magdalena ^{[2
]}

Sledzinski, Tomasz ^{[3
]}

Korczynska, Justyna ^{[3
]}

Goyke, Elzbieta ^{[1
]}

Swierczynski, Julian ^{[1
]}

机构：

[1] Med Univ Gdansk, Dept Biochem, PL-80211 Gdansk, Poland

[2] Med Univ Gdansk, Dept Gastroenterol & Hepatol, PL-80211 Gdansk, Poland

[3] Med Univ Gdansk, Dept Pharmaceut Biochem, PL-80211 Gdansk, Poland

来源：

PANCREATOLOGY | 2011年 / 11卷 / 04期

关键词：

Platelet-derived growth factor-BB; Transforming growth factor-beta 1; Laminin; Hyaluronic acid; Pancreatitis; chronic; CHRONIC HEPATITIS-C; FIBROBLAST-LIKE CELLS; STELLATE CELLS; EXTRACELLULAR-MATRIX; LIVER-CIRRHOSIS; FACTOR-BETA; FIBROSIS; CYTOKINES; PROLIFERATION; EXPRESSION;

D O I：

10.1159/000330294

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Background: In vitro studies suggest that platelet-derived growth factor-BB (PDGF-BB) and transforming growth factor-beta 1 (TGF-beta 1) play an important role in pancreatic fibrosis. The aim of this study was to evaluate serum PDGF-BB and TGF-beta 1 concentrations in patients with chronic pancreatitis (CP). Methods: Forty male patients with a history of alcoholic CP and 35 age-matched healthy subjects were examined. Serum concentrations of PDGF-BB, TGF-beta 1, laminin and hyaluronic acid were determined by ELISA assay. Additionally, we determined serum concentrations of PDGF-BB and TGF-beta 1 in patients with functional dyspepsia, ulcerative colitis and Crohn's disease. Results: Patients with advanced CP had significantly higher serum PDGF-BB and TGF-beta 1 concentrations compared to control subjects. A strong positive correlation between serum PDGF-BB and TGF-beta 1 concentrations was found in patients with CP. Serum laminin and hyaluronic acid were also elevated in patients with CP. No increase in serum PDGF-BB and TGF-beta 1 concentrations was found in patients with functional dyspepsia, ulcerative colitis or Crohn's disease. Conclusion: The obtained results indicate for the first time that serum levels of PDGF-BB are elevated in patients with CP. However, ROC curve analysis suggests that PDGF-BB is not superior to laminin as a potential marker of advanced CP. Copyright (C) 2011 S. Karger AG, Basel and IAP

引用

页码：434 / 440

页数：7

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