Regulation of mitochondrial antiviral signaling pathways

被引：69

作者：

Moore, Chris B. ^{[1
]}

Ting, Jenny P-Y. ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA

来源：

IMMUNITY | 2008年 / 28卷 / 06期

关键词：

D O I：

10.1016/j.immuni.2008.05.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mitochondrial antiviral immunity involves the detection of viral RNA by intracellular pattern-recognition receptors (PRRs) belonging to the RIG-I-like helicase family. The convergence of these and other signaling molecules to the outer mitochondrial membrane results in the rapid induction of antiviral cytokines including type-1 interferon. Here, we discuss recent studies describing new molecules implicated in the regulation of this antiviral response.

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页码：735 / 739

页数：5

相关论文

共 27 条

[1] Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125 [J].

Arimoto, Kei-ichiro ;

Takahashi, Hitoshi ;

Hishiki, Takayuki ;

Konishi, Hicleyuki ;

Fujita, Takashi ;

Shimotohno, Kunitada .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (18) :7500-7505

[2] Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells [J].

Cheng, Guofeng ;

Zhong, Jin ;

Chung, Josan ;

Chisari, Francis V. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (21) :9035-9040

[3] Plant NBS-LRR proteins in pathogen sensing and host defense [J].

DeYoung, Brody J. ;

Innes, Roger W. .

NATURE IMMUNOLOGY, 2006, 7 (12) :1243-1249

[4] Does Toll-like receptor 3 play a biological role in virus infections? [J].

Edelmann, KH ;

Richardson-Burns, S ;

Alexopoulou, L ;

Tyler, KL ;

Flavell, RA ;

Oldstone, MBA .

VIROLOGY, 2004, 322 (02) :231-238

[5] TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity [J].

Gack, Michaela U. ;

Shin, Young C. ;

Joo, Chul-Hyun ;

Urano, Tomohiko ;

Liang, Chengyu ;

Sun, Lijun ;

Takeuchi, Osamu ;

Akira, Shizuo ;

Chen, Zhijian ;

Inoue, Satoshi ;

Jung, Jae U. .

NATURE, 2007, 446 (7138) :916-U2

[6] TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines [J].

Ishii, Ken J. ;

Kawagoe, Tatsukata ;

Koyama, Shohei ;

Matsui, Kosuke ;

Kumar, Himanshu ;

Kawai, Taro ;

Uematsu, Satoshi ;

Takeuchi, Osamu ;

Takeshita, Fumihiko ;

Coban, Cevayir ;

Akira, Shizuo .

NATURE, 2008, 451 (7179) :725-U6

[7]

JANEWAY CA, 1989, COLD SH Q B, V54, P1

[8] The Atg5-Atg12 conjugate associates with innate antiviral immune responses [J].

Jounai, Nao ;

Takeshita, Fumihiko ;

Kobiyama, Kouji ;

Sawano, Asako ;

Miyawaki, Atsushi ;

Xin, Ke-Qin ;

Ishii, Ken J. ;

Kawaii, Taro ;

Akira, Shizuo ;

Suzuki, Koichi ;

Okuda, Kenji .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (35) :14050-14055

[9] IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction [J].

Kawai, T ;

Takahashi, K ;

Sato, S ;

Coban, C ;

Kumar, H ;

Kato, H ;

Ishii, KJ ;

Takeuchi, O ;

Akira, S .

NATURE IMMUNOLOGY, 2005, 6 (10) :981-988

[10] DUBA: A deubiquitinase that regulates type I interferon production [J].

Kayagaki, Nobuhiko ;

Phung, Qui ;

Chan, Salina ;

Chaudhari, Ruchir ;

Quan, Casey ;

O'Rourke, Karen M. ;

Eby, Michael ;

Pietras, Eric ;

Cheng, Genhong ;

Bazan, J. Fernando ;

Zhang, Zemin ;

Arnott, David ;

Dixit, Vishva M. .

SCIENCE, 2007, 318 (5856) :1628-1632