Modulation of the immunogenicity of antigenic determinants by their flanking residues

被引:87
作者
Moudgil, KD
Sercarz, EE
Grewal, IS
机构
[1] La Jolla Inst Allergy & Immunol, San Diego, CA 92121 USA
[2] Yale Univ, Sch Med, Immunobiol Sect, New Haven, CT 06510 USA
来源
IMMUNOLOGY TODAY | 1998年 / 19卷 / 05期
关键词
D O I
10.1016/S0167-5699(97)01233-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Much of the attention on protein antigens and their induction of T-cell responses has focused on the nature of the interactions of their 'core' determinants with the major histocompatibility complex (MHC) or the T-cell receptor (TCR). Here, Kamal Moudgil and colleagues instead emphasize the vital role of the amino acid residues that flank the core antigenic determinant on the outcome of the response.
引用
收藏
页码:217 / 220
页数:4
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