The Expanding Spectrum of Eschar-Associated Rickettsioses in the United States

被引：54

作者：

Cragun, W. Chad ^{[1
]}

Bartlett, Brenda L. ^{[3
]}

Ellis, Michael W. ^{[4
]}

Hoover, Aaron Z. ^{[1
]}

Tyring, Stephen K. ^{[3
,5
]}

Mendoza, Natalia ^{[3
,6
]}

Vento, Todd J. ^{[2
]}

Nicholson, William L. ^{[7
]}

Eremeeva, Marina E. ^{[7
]}

Olano, Juan P. ^{[8
,10
]}

Rapini, Ronald P. ^{[8
,9
]}

Paddock, Christopher D. ^{[7
]}

机构：

[1] San Antonio Mil Med Ctr, Dermatol Serv, San Antonio, TX USA

[2] San Antonio Mil Med Ctr, Infect Dis Serv, San Antonio, TX USA

[3] Ctr Clin Studies, Houston, TX USA

[4] Uniformed Serv Univ Hlth Sci, Dept Med, Div Infect Dis, Bethesda, MD 20814 USA

[5] Univ Texas Med Sch, Dept Dermatol, Houston, TX USA

[6] El Bosque Univ, Bogota, Colombia

[7] Ctr Dis Control & Prevent, Div Viral & Rickettsial Dis, Atlanta, GA USA

[8] Univ Texas Med Branch Galveston, Dept Pathol, Galveston, TX USA

[9] Univ Texas Med Branch Galveston, Dept Dermatol, Galveston, TX USA

[10] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX USA

来源：

ARCHIVES OF DERMATOLOGY | 2010年 / 146卷 / 06期

关键词：

MOUNTAIN-SPOTTED-FEVER; NEWLY RECOGNIZED CAUSE; PARKERI INFECTION; TRAVELERS; DISEASE; AFRICA;

D O I：

10.1001/archdermatol.2010.48

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Background: Until recently, Rickettsia rickettsii was the only substantiated cause of tick-borne spotted fever group (SFG) rickettsiosis in humans in the United States. Rickettsia parkeri, originally thought to be nonpathogenic in humans, was recently proved to be another cause of tick-borne SFG rickettsiosis. Observations: We report 3 cases of SFG rickettsiosis and discuss the epidemiology, clinical presentation, histopathologic features, and laboratory findings that support confirmed or probable diagnoses of R parkeri infection and describe the expanding list of eschar-associated SFC rickettsioses recognized in US patients. Conclusions: The SFG rickettsioses share many clinical manifestations and extensive antigenic cross-reactivity that may hamper specific confirmation of the causative agent.

引用

页码：641 / 648

页数：8

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