Neuronal subserving of behavior before and after chronic ethanol treatment

被引：8

作者：

Alexandrov, YI ^{[1
]}

Grinchenko, YV

Bodunov, MV

Matz, VN

Korpusova, AV

Laukka, S

Sams, M

机构：

[1] Russian Acad Sci, Inst Psychol, Lab Neural Basis Mind, Moscow 129366, Russia

[2] Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Lab Morphol Cent Nervous Syst, Moscow 117865, Russia

[3] Oulu Univ, Dept Behav Sci, SF-90571 Oulu, Finland

[4] Aalto Univ, Lab Computat Engn, FIN-02015 Helsinki, Finland

来源：

ALCOHOL | 2000年 / 22卷 / 02期

基金：

芬兰科学院;

关键词：

neuron; behavior; cingulate cortex; ethanol;

D O I：

10.1016/S0741-8329(00)00111-7

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

We have previously shown that an acute ethanol dose (1 g/kg), sufficient to impair the performance of a healthy rabbit, also reversibly depresses the activity of those limbic-cortex neurons that are specifically activated during recently learned behavioral acts. Our new morphological and neurophysiological data suggest a death of such neurons after 9-month chronic ethanol treatment. The effect of acute ethanol administration on neurons and performance speed in alcoholic rabbits was opposite to that found in healthy animals. Our results help to understand why neurocognition of alcoholics changes and why acute low-level alcohol ingestion influences them differently than healthy individuals. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：97 / 106

页数：10

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