Overexpression of glucose transporter protein 5 in sciatic nerve of streptozotocin-induced diabetic rats

被引：6

作者：

Asada, T

Takakura, S

Ogawa, T

Iwai, M

Kobayashi, M

机构：

[1] Fujisawa Pharmaceut Co Ltd, Mol Biol Res Labs, Yodogawa Ku, Osaka 5328514, Japan

[2] Fujisawa Pharmaceut Co Ltd, Pharmaceut Res Labs, Osaka 5328514, Japan

[3] Marine Technol Coll, Dept Chem, Ashiya 6590026, Japan

[4] Northwestern Univ, Fujidawa Res Inst Amer, Evanston, IL 60201 USA

来源：

NEUROSCIENCE LETTERS | 1998年 / 252卷 / 02期

关键词：

rat; diabetic neuropathy; sciatic nerve; glucose transporter; insulin-like growth factor-I; insulin; immunohistochemistry; Western blotting;

D O I：

10.1016/S0304-3940(98)00560-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The localization and the expression level of glucose transporter 5 (GLUT 5), detected by immunohistochemical and Western blot analyses, and motor nerve conduction velocity (MNCV) in normal and streptozotocin (STZ)-induced diabetic rats were compared. The effects of insulin and recombinant human insulin-like growth factor-I (rhlGF-I) were also investigated. GLUT 5 was localized in Schwann cells and axons. GLUT 5 was overexpressed in both sites 5 weeks after STZ injection and MNCV was decreased significantly in STZ-induced diabetic rats as compared with normal rats. These deviations returned to normal rat level after 2 weeks medication with insulin or rhIGF-I, started 3 weeks after STZ injection. These results suggest that overexpression of GLUT 5 may be a trigger for diabetic neuropathy. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved

引用

页码：111 / 114

页数：4

共 21 条

[1] Recombinant insulin-like growth factor I normalizes expression of renal glucose transporters in diabetic rats [J].