An allylation-metathesis sequence as a convergent strategy towards enantiopure equivalents of highly functionalized cyclic dienes

被引：10

作者：

de Fays, L

Adam, JM

Ghosez, L

机构：

[1] ENSCPB, Inst Europeen Chim & Biol, F-33607 Pessac, France

[2] Univ Catholique Louvain, Dept Chim, B-1348 Louvain, Belgium

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 38期

关键词：

D O I：

10.1016/S0040-4039(03)01791-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly enantioenriched equivalents of cyclic dienes have been readily prepared by asymmetric allylation of unsaturated aldehydes using a chiral allyltitanium reagent, followed by a ring-closing metathesis. The resulting beta-hydroxy allylsilanes react stereoselectively with a wide variety of electrophilic reagents. (C) 2003 Elsevier Ltd. All rights reserved.

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收藏

页码：7197 / 7199

页数：3

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