Dibasic inhibitors of human mast cell tryptase. Part 3: Identification of a series of potent and selective inhibitors containing the benzamidine functionality

被引：15

作者：

Dener, JM

Rice, KD

Newcomb, WS

Wang, VR

Young, WB

Gangloff, AR

Kuo, EYL

Cregar, L

Putnam, D

Wong, M

机构：

[1] Axys Pharmaceut Inc, Dept Med Chem, San Francisco, CA 94080 USA

[2] Axys Pharmaceut Inc, Dept Biochem, San Francisco, CA 94080 USA

[3] Axys Pharmaceut Inc, Dept Enzymol, San Francisco, CA 94080 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(01)00254-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A survey of charged groups and linkers for a series of symmetrical and unsymmetrical dibasic inhibitors is described. leading to several classes of potent and selective inhibitors. In particular. the benzamidine functionality was identified as the most potent charged group investigated. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1629 / 1633

页数：5

共 13 条

[1] SYNTHETIC INHIBITORS OF ELASTASE [J].