The role of peripheral N-methyl-D-aspartate receptors in muscle hyperalgesia

被引：30

作者：

Ro, JY ^{[1
]}

Nies, M ^{[1
]}

Zhang, YP ^{[1
]}

机构：

[1] Univ Maryland, Sch Dent, Dept Biomed Sci, Baltimore, MD 21201 USA

来源：

NEUROREPORT | 2005年 / 16卷 / 05期

关键词：

behavior; complete Freund's adjuvant; masseter; muscle hyperalgesia; peripheral N-methyl-D-aspartate receptors; rodent;

D O I：

10.1097/00001756-200504040-00013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The present study demonstrates that intramuscular administration of N-methyl-D-aspartate receptor antagonist AP5 dose-dependently attenuates complete Freund's adjuvant (CFA) induced muscular hyperalgesia. CFA significantly reduced mean bite force and success rate in the rats trained to produce a specific bite force. Pretreatment with AP5 reversed the overall magnitude of reduction in mean bite force and success rate in CFA inflamed rats, and significantly facilitated the recovery of these measures to pre-injection level. AP5 treatment 1 day after the CFA injection had little effect on CFA-mediated changes in bite force measurements. These data suggest that peripheral N-methyl-D-aspartate receptors play a critical role in the development of persistent muscle hyperalgesia, and provide important new insights for therapeutic alternatives that can be directed at the periphery. (c) 2005 Lippincott Williams T Wilkins.

引用

页码：485 / 489

页数：5

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