Large clonal expansions of CD8(+) T cells in acute infectious mononucleosis

被引：395

作者：

Callan, MFC ^{[1
]}

Steven, J ^{[1
]}

Krausa, P ^{[1
]}

Wilson, JDK ^{[1
]}

Moss, PAH ^{[1
]}

Gillespie, GM ^{[1
]}

Bell, JI ^{[1
]}

Rickinson, AB ^{[1
]}

McMichael, AJ ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,CRC,INST CANC STUDIES,SCH MED,BIRMINGHAM B15 2TJ,W MIDLANDS,ENGLAND

来源：

NATURE MEDICINE | 1996年 / 2卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nm0896-906

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Primary infection with Epstein-Barr virus often results in the clinical syndrome of acute infectious mononucleosis (glandular fever). This illness is characterized by a striking lymphocytosis, the nature of which has been controversial. We show that large monoclonal or oligoclonal populations of CD8(+) T cells account for a significant proportion of the lymphocytosis and provide molecular evidence that these populations have been driven by antigen. The results suggest that the selective and massive expansion of a few dominant clones of CD8(+) T cells is an important feature of the primary response to this virus.

引用

页码：906 / 911

页数：6

共 43 条

[1] DOMINANT SELECTION OF AN INVARIANT T-CELL ANTIGEN RECEPTOR IN RESPONSE TO PERSISTENT INFECTION BY EPSTEIN-BARR-VIRUS [J].

ARGAET, VP ;

SCHMIDT, CW ;

BURROWS, SR ;

SILINS, SL ;

KURILLA, MG ;

DOOLAN, DL ;

SUHRBIER, A ;

MOSS, DJ ;

KIEFF, E ;

SCULLEY, TB ;

MISKO, IS .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (06) :2335-2340

[2] TISSUE TYPING THE HLA-A LOCUS FROM GENOMIC DNA BY SEQUENCE-SPECIFIC PCR - COMPARISON OF HLA GENOTYPE AND SURFACE EXPRESSION ON COLORECTAL TUMOR-CELL LINES [J].

BROWNING, MJ ;

KRAUSA, P ;

ROWAN, A ;

BICKNELL, DC ;

BODMER, JG ;

BODMER, WF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (07) :2842-2845

[3] A METHOD FOR PRODUCING MONOCLONAL-ANTIBODIES TO HUMAN T-CELL-RECEPTOR BETA-CHAIN VARIABLE REGIONS [J].

CALLAN, MFC ;

REYBURN, HT ;

BOWNESS, P ;

OTTENHOFF, TH ;

ENGEL, I ;

KLAUSNER, RD ;

BELL, JI ;

MCMICHAEL, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (22) :10454-10458

[4] SELECTION OF T-CELL RECEPTOR VARIABLE GENE-ENCODED AMINO-ACIDS ON THE 3RD BINDING-SITE LOOP - A FACTOR INFLUENCING VARIABLE CHAIN SELECTION IN A T-CELL RESPONSE [J].

CALLAN, MFC ;

REYBURN, HT ;

BOWNESS, P ;

ROWLANDJONES, S ;

BELL, JI ;

MCMICHAEL, AJ .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (06) :1529-1534

[5] QUANTITATIVE-ANALYSIS OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1)-SPECIFIC CYTOTOXIC LYMPHOCYTE-T (CTL) RESPONSE AT DIFFERENT STAGES OF HIV-1 INFECTION - DIFFERENTIAL CTL RESPONSES TO HIV-1 AND EPSTEIN-BARR-VIRUS IN LATE DISEASE [J].

CARMICHAEL, A ;

JIN, X ;

SISSONS, P ;

BORYSIEWICZ, L .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) :249-256

[6] EXPRESSION ON HUMAN THYMOCYTES OF THE IDIOTYPIC STRUCTURES (TI) FROM 2 LEUKEMIA T-CELL LINES JURKAT AND HPB-ALL [J].

CARREL, S ;

ISLER, P ;

SCHREYER, M ;

VACCA, A ;

SALVI, S ;

GIUFFRE, L ;

MACH, JP .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1986, 16 (06) :649-652

[7] T-CELL RECEPTOR V-BETA REPERTOIRE IN AN ACUTE INFECTION OF RHESUS-MONKEYS WITH SIMIAN IMMUNODEFICIENCY VIRUSES AND A CHIMERIC SIMIAN-HUMAN IMMUNODEFICIENCY VIRUS [J].

CHEN, ZW ;

KOU, ZC ;

LEKUTIS, C ;

SHEN, L ;

ZHOU, DJ ;

HALLORAN, M ;

LI, J ;

SODROSKI, J ;

LEEPARRITZ, D ;

LETVIN, NL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (01) :21-31

[8] A METHOD FOR PRODUCTION OF ANTIBODIES TO HUMAN T-CELL RECEPTOR BETA-CHAIN VARIABLE REGIONS [J].

CHOI, YW ;

KOTZIN, B ;

LAFFERTY, J ;

WHITE, J ;

PIGEON, M ;

KUBO, R ;

KAPPLER, J ;

MARRACK, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (19) :8357-8361

[9] INTERACTION OF STAPHYLOCOCCUS-AUREUS TOXIN SUPERANTIGENS WITH HUMAN T-CELLS [J].

CHOI, YW ;

KOTZIN, B ;

HERRON, L ;

CALLAHAN, J ;

MARRACK, P ;

KAPPLER, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8941-8945

[10] BIMODAL DISTRIBUTION OF V-BETA-2(+)CD4(+) T-CELLS IN HUMAN PERIPHERAL-BLOOD [J].

CLARKE, GR ;

REYBURN, H ;

LANCASTER, FC ;

BOYLSTON, AW .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1994, 24 (04) :837-842

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