To live and let die

被引:5
作者
Gerondakis, S [1 ]
Strasser, A [1 ]
机构
[1] PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
关键词
D O I
10.1038/87669
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Adjuvants and inflammation inhibit TCR ligation-induced apoptosis of T cells. Bcl-3 may enhance the increased T cell survival by positive regulation of NF-κB transcription factors.
引用
收藏
页码:377 / 379
页数:3
相关论文
共 13 条
  • [1] Proapoptotic Bcl-2 relative bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
    Bouillet, P
    Metcalf, D
    Huang, DCS
    Tarlinton, DM
    Kay, TWH
    Köntgen, F
    Adams, JM
    Strasser, A
    [J]. SCIENCE, 1999, 286 (5445) : 1735 - 1738
  • [2] Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions
    Franzoso, G
    Carlson, L
    SchartonKersten, T
    Shores, EW
    Epstein, S
    Grinberg, A
    Tran, T
    Shacter, E
    Leonardi, A
    Anver, M
    Love, P
    Sher, A
    Siebenlist, U
    [J]. IMMUNITY, 1997, 6 (04) : 479 - 490
  • [3] THE CANDIDATE ONCOPROTEIN BCL-3 IS AN ANTAGONIST OF P50/NF-KAPPA-B-MEDIATED INHIBITION
    FRANZOSO, G
    BOURS, V
    PARK, S
    TOMITAYAMAGUCHI, M
    KELLY, K
    SIEBENLIST, U
    [J]. NATURE, 1992, 359 (6393) : 339 - 342
  • [4] Gugasyan R, 2000, IMMUNOL REV, V176, P134
  • [5] THE PROTOONCOGENE BCL-3 ENCODES AN I-KAPPA-B PROTEIN
    KERR, LD
    DUCKETT, CS
    WAMSLEY, P
    ZHANG, Q
    CHIAO, P
    NABEL, G
    MCKEITHAN, TW
    BAEUERLE, PA
    VERMA, IM
    [J]. GENES & DEVELOPMENT, 1992, 6 (12A) : 2352 - 2363
  • [6] Immunological adjuvants promote activated T cell survival via induction of Bcl-3
    Mitchell, TC
    Hildeman, D
    Kedl, RM
    Teague, TK
    Schaefer, BC
    White, J
    Zhu, YN
    Kappler, J
    Marrack, P
    [J]. NATURE IMMUNOLOGY, 2001, 2 (05) : 397 - 402
  • [7] Cell death control in lymphocytes
    Newton, K
    Strasser, A
    [J]. ADVANCES IN IMMUNOLOGY, VOL. 76, 2001, 76 : 179 - 226
  • [8] Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice
    Ong, ST
    Hackbarth, ML
    Degenstein, LC
    Baunoch, DA
    Anastasi, J
    McKeithan, TW
    [J]. ONCOGENE, 1998, 16 (18) : 2333 - 2343
  • [9] Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors
    Rebollo, A
    Dumoutier, L
    Renauld, JC
    Zaballos, A
    Ayllón, V
    Martínez-A, C
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (10) : 3407 - 3416
  • [10] Interleukin-9 regulates NF-κB activity through BCL3 gene induction
    Richard, M
    Louahed, J
    Demoulin, JB
    Renauld, JC
    [J]. BLOOD, 1999, 93 (12) : 4318 - 4327