The nucleoplasmic reticulum: form and function

被引：195

作者：

Malhas, Ashraf ^{[1
]}

Goulbourne, Chris ^{[1
]}

Vaux, David J. ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

TRENDS IN CELL BIOLOGY | 2011年 / 21卷 / 06期

基金：

英国医学研究理事会;

关键词：

HIV-PROTEASE INHIBITORS; INNER NUCLEAR-MEMBRANE; CYTOMEGALOVIRUS PRIMARY ENVELOPMENT; ACUTE MYELOID-LEUKEMIA; RATE-LIMITING ENZYME; PHOSPHATIDYLCHOLINE SYNTHESIS; INTERPHASE NUCLEI; DROSOPHILA-MELANOGASTER; NUCLEOPORIN NUP153; GENE-EXPRESSION;

D O I：

10.1016/j.tcb.2011.03.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The nuclear envelope (NE) physically separates nucleoplasm and cytoplasm, contributes to nuclear structural integrity, controls selective bidirectional transport of ions and macromolecular cargo, regulates gene expression, and acts as a mechanotransducer and a platform for signalling. It is noteworthy however that the NE is not simply a smooth-surfaced outer boundary but is interrupted by invaginations that reach deep within the nucleoplasm and could even traverse the nucleus completely. The existence of such a complex branched network of invaginations forming a nucleoplasmic reticulum (NR) provides sites that are capable of carrying out the 'conventional' NE functions deep within the nucleus in regions that would otherwise be remote from the nuclear periphery. In this review, we describe the structural features of NR in normal and pathological states and discuss the current understanding of their functional and possible pathological roles.

引用

页码：362 / 373

页数：12

共 140 条

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Myocyte differentiation generates nuclear invaginations traversed by myofibrils associating with sarcomeric protein mRNAs [J].