Analysis of peripheral blood leukocytes in patients with cyclosporine A-induced gingival hyperplasia

被引:9
作者
Cebeci, I
Kantarci, A
Gürel, N
Adin, S
Tuncer, Ö
Çarin, M
Badur, S
Firatli, E [1 ]
机构
[1] Istanbul Univ, Sch Dent, Dept Periodontol, TR-34390 Istanbul, Turkey
[2] Istanbul Sch Med, Dept Virol & Basic Immunol, Istanbul, Turkey
[3] Istanbul Sch Med, Transplantat Unit, Istanbul, Turkey
[4] Istanbul Sch Med, Dept Med Biol, Istanbul, Turkey
关键词
lymphocyte; natural killer cell; monocyte; gingiva/hyperplasia; cyclosporine; flow-cytometry;
D O I
10.1902/jop.1998.69.12.1435
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Background: Gingival overgrowth is one of the major adverse effects of the immunosuppressive drug cyclosporine A (CsA). Although several studies have attempted to determine the immunological mechanisms of gingival hyperplasia (GO) due to CsA therapy, the pathogenesis remains unclear. In this study the distribution of the peripheral blood leukocytes in a group of renal transplant patients undergoing CsA therapy was analyzed and possible correlations of periodontal and pharmacological variables to lymphocyte subpopulations, natural killer cells, and monocytes investigated. Methods: Thirty-six patients were classified into 2 groups of 18 each according to the degree of gingival overgrowth. The periodontal evaluation included plaque index (PI), gingival index (GI), gingival overgrowth (GO), calculus index (CI), and probing depth (PD). The pharmacological variables of current doses of the therapeutic serum levels of CsA were investigated. The peripheral blood leukocytes were studied by 2-color flow cytometric analysis using anti-human CD2, CD3, CD4, CD8, CD11b, CD11c, CD16, CD19, HLA-DR, and CD3+HLA-DR+ monoclonal antibodies. Results: Statistical evaluation revealed that none of the pharmacological variables varied between the 2 groups. Responders (GO >30%) had significantly higher GI, PD, and GO scores compared to nonresponders (GO less than or equal to 30%). Of the immunological parameters studied, only CD2 was higher in the responder group. None of the clinical parameters correlated to the immunological values. Conclusions: The results of this study may be useful in explaining the underlying mechanisms of drug-induced gingival overgrowth. Several previously unsuspected cells and accessory activation mechanisms for T lymphocytes could play a role in the pathogenesis.
引用
收藏
页码:1435 / 1439
页数:5
相关论文
共 33 条
[1]   GENETIC AND MUTATIONAL ANALYSIS OF THE T-CELL ANTIGEN RECEPTOR [J].
ASHWELL, JD ;
KLAUSNER, RD .
ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 :139-167
[2]   BIOLOGICAL EFFECTS OF CYCLOSPORIN-A - NEW ANTILYMPHOCYTIC AGENT [J].
BOREL, JF ;
FEURER, C ;
GUBLER, HU ;
STAHELIN, H .
AGENTS AND ACTIONS, 1976, 6 (04) :468-475
[3]   The effect of verapamil on the prevalence and severity of cyclosporine-induced gingival overgrowth in renal allograft recipients [J].
Cebeci, I ;
Kantarci, A ;
Firatli, E ;
Carin, M ;
Tuncer, O .
JOURNAL OF PERIODONTOLOGY, 1996, 67 (11) :1201-1205
[4]   Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine-A [J].
Cebeci, I ;
Kantarci, A ;
Firatli, E ;
Aygun, S ;
Tanyeri, H ;
Aydin, AE ;
Carin, M ;
Guc, U ;
Tuncer, O .
JOURNAL OF CLINICAL PERIODONTOLOGY, 1996, 23 (08) :737-742
[5]   CLINICAL AND PHARMACOLOGICAL CORRELATIONS IN CYCLOSPORINE-INDUCED GINGIVAL HYPERPLASIA [J].
DALEY, TD ;
WYSOCKI, GP ;
DAY, C .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1986, 62 (04) :417-421
[6]   CYCLOSPORINE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES, AND THERAPEUTIC USE IN IMMUNOREGULATORY DISORDERS [J].
FAULDS, D ;
GOA, KL ;
BENFIELD, P .
DRUGS, 1993, 45 (06) :953-1040
[7]  
HASSELL T M, 1991, Critical Reviews in Oral Biology and Medicine, V2, P103
[8]  
Hassell T M, 1994, Periodontol 2000, V6, P68, DOI 10.1111/j.1600-0757.1994.tb00027.x
[9]  
HERBERMAN RB, 1986, ANNU REV IMMUNOL, V4, P651, DOI 10.1146/annurev.iy.04.040186.003251
[10]  
HESS AD, 1986, PROG ALLERGY, V38, P198