Modulators of Notch signaling

被引:65
作者
Panin, VM
Irvine, KD
机构
[1] Rutgers State Univ, Waksman Inst, Piscataway, NJ 08854 USA
[2] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08854 USA
关键词
development; lin-12; modulator; Notch; signaling;
D O I
10.1006/scdb.1998.0263
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In addition to the core components of the Notch pathway, a number of proteins have been identified that exert positive or negative influences on Notch signaling These include extracellular modulators, which may influence binding or activation of Notch by its ligands, cytoplasmic modulators, which presumably influence signal transduction steps after receptor activation, and nuclear modulators, which may influence the transcriptional activity of a Notch-CSL protein complex, Many of the cytoplasmic and nuclear modulators appear to bind directly to discrete domains within the intracellular domain of Notch. Genetic studies indicate that distinct modulators are deployed during distinct modes of Notch signaling.
引用
收藏
页码:609 / 617
页数:9
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