Identification of an efflux pump gene, pmrA, associated with fluoroquinolone resistance in Streptococcus pneumoniae

被引：206

作者：

Gill, MJ ^{[1
]}

Brenwald, NP

Wise, R

机构：

[1] Univ Birmingham, Sch Med, Dept Infect, Div Immun & Infect, Birmingham B15 2TT, W Midlands, England

[2] City Hosp NHS Trust, Dept Microbiol, Birmingham B18 7QH, W Midlands, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 01期

关键词：

D O I：

10.1128/AAC.43.1.187

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An open reading frame (ORF) homologous to norA was insertionally inactivated with cat in a fluoroquinolone-resistant pneumococcus with an efflux phenotype; this inactivation caused reversion to drug sensitivity. The ORF product has 24% amino acid sequence identity each to NorA and Bmr, which suggests that it is a major facilitator system pump of the 12-transmembrane-segment class.

引用

页码：187 / 189

页数：3

共 13 条

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