Heterogeneous lack of expression of the tumour suppressor PTEN protein in human neoplastic tissues

被引：42

作者：

Torres, J

Navarro, S

Roglá, I

Ripoll, F

Lluch, A

García-Conde, J

Llombart-Bosch, A

Cervera, J

Pulido, R

机构：

[1] Inst Invest Citol, Valencia 46010, Spain

[2] Univ Valencia, Dept Patol, Valencia, Spain

[3] Univ Valencia, Hosp Clin Valencia, Serv Oncol & Hematol, Valencia, Spain

来源：

EUROPEAN JOURNAL OF CANCER | 2001年 / 37卷 / 01期

关键词：

PTEN; tumour suppressor; cancer; protein phosphatases;

D O I：

10.1016/S0959-8049(00)00366-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PTEN, a tumour suppressor gene located at chromosome 10q23 and commonly mutated or deleted in a variety of tumours, encodes a dual-specific/phosphatidylinositol-3,4,5-triphosphate (PIP3) phosphatase. We report the generation of an anti-PTEN monoclonal antibody (MAb) that recognises an epitope at the C-terminus of PTEN, and describe the heterogeneous lack of expression of the PTEN protein in human tumour tissues, as demonstrated by immunohistochemical methods. Our anti-PTEN MAb provides a useful tool for the study of PTEN protein expression in tumour samples, in the search for tumour prognostic molecular markers. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：114 / 121

页数：8

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