Emerging properties of animal gene regulatory networks

被引：413

作者：

Davidson, Eric H. ^{[1
]}

机构：

[1] CALTECH, Div Biol 156 29, Pasadena, CA 91125 USA

来源：

NATURE | 2010年 / 468卷 / 7326期

关键词：

FEEDFORWARD LOOP; DORSAL GRADIENT; FOLD-CHANGE; EXPRESSION; CELLS; DIFFERENTIATION; PATTERN; SYSTEM; FATE; PROLIFERATION;

D O I：

10.1038/nature09645

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gene regulatory networks (GRNs) provide system level explanations of developmental and physiological functions in the terms of the genomic regulatory code. Depending on their developmental functions, GRNs differ in their degree of hierarchy, and also in the types of modular sub-circuit of which they are composed, although there is a commonly employed sub-circuit repertoire. Mathematical modelling of some types of GRN sub-circuit has deepened biological understanding of the functions they mediate. The structural organization of various kinds of GRN reflects their roles in the life process, and causally illuminates both developmental and evolutionary process.

引用

收藏

页码：911 / 920

页数：10

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