6-heteroaryl-pyrazolo[3,4-b]pyridines:: Potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)

被引：84

作者：

Witherington, J ^{[1
]}

Bordas, V ^{[1
]}

Gaiba, A ^{[1
]}

Naylor, A ^{[1
]}

Rawlings, AD ^{[1
]}

Slingsby, BP ^{[1
]}

Smith, DG ^{[1
]}

Takle, AK ^{[1
]}

Ward, RW ^{[1
]}

机构：

[1] GlaxoSmithKline Res Ltd, Dept Med Chem, Neurol & GI Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(03)00646-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 6-heteroaryl-pyrazolo[3,4-b]pyridines has been optimised to afford potent inhibitors of Glycogen Synthase Kinase-3 (GSK-3). These analogues display excellent selectivity over the closely related Cyclin Dependant Kinase-2 (CDK-2). (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3059 / 3062

页数：4

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