20-fold increase in risk of lamivudine resistance in hepatitis B virus subtype adw

被引：111

作者：

Zöllner, B

Petersen, J

Schröter, M

Laufs, R

Schoder, V

Feucht, HH

机构：

[1] Univ Hamburg, Hosp Eppendorf, Inst Med Microbiol & Immunol, D-20246 Hamburg, Germany

[2] Univ Hamburg, Hosp Eppendorf, Dept Internal Med, Heinrich Pette Inst Expt Virol & Immunol, D-20246 Hamburg, Germany

[3] Univ Hamburg, Hosp Eppendorf, Inst Math & Data Sci Med, D-20246 Hamburg, Germany

来源：

LANCET | 2001年 / 357卷 / 9260期

关键词：

D O I：

10.1016/S0140-6736(00)04219-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated subtype-dependent development of lamivudine resistance In hepatitis B virus (HBV) longitudinally In 26 consecutive patients (13 adw and 13 ayw carriers) during antiviral treatment of chronic hepatitis B, Lamivudine resistance developed in seven adw carriers and one ayw carrier. Risk of lamivudine resistance was significantly higher for adw carriers than for ayw carriers (p=0.03). We believe that the adw subtype of HBV Is associated with a high risk of lamivudine resistance, which might be linked to simultaneous changes of the HBsAg that occurs with the emergence of resistance.

引用

页码：934 / 935

页数：2

共 5 条

[1] Identification and characterization of mutations in hepatitis B virus resistant to lamivudine [J].