Synchronous and metachronous squamous cell carcinomas of the head and neck mucosal sites

被引:117
作者
Erkal, HS
Mendenhall, WM
Amdur, RJ
Villaret, DB
Stringer, SP
机构
[1] Univ Florida, Dept Radiat Oncol, Ctr Sci, Coll Med, Gainesville, FL 32610 USA
[2] Univ Florida, Coll Med, Dept Otolaryngol, Gainesville, FL 32610 USA
[3] Inonli Univ, Fac Med, Dept Radiat Oncol, Malatya, Turkey
关键词
D O I
10.1200/JCO.2001.19.5.1358
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: The present study presents the experience at the University of Florida with synchronous and meta-chronous squamous cell carcinomas of the head and neck mucosal sites. Patients and Methods: This study included 1,112 patients with squamous cell carcinomas of the oropharynx, hypopharynx, and supraglottic larynx treated with radiation therapy with curative intent from 1964 to 1997. All patients had follow-up far at least 2 years. No patients were lost to follow-up. Results: The overall survival rate was 45% and the disease-specific survival rate wets 67% at 5 years after initial diagnosis of carcinoma of the head and neck mucosal sites. Seventy-seven patients (7%) presented with synchronous carcinomas of the head and neck mucosal sites and 103 patients (9%) developed meta-chronous carcinomas of the head and neck mucosal sites at 0.6 to 21.7 years (median, 3.6 years). The overall survival rate wets 31%, and the disease-specific survival rate was 50% at 5 years after metachronous carcinomas of the head and neck mucosal sites. Seven patients (1%) developed metachronous carcinomas of the thoracic esophagus at 1 to 11.1 years (median, 2.8 years), 15 patients (1%) presented with synchronous carcinomas of the lung, and 83 patients (7%) developed metachronous carcinomas of the lung at 0.6 to 17.6 years (median, 3.5 years). Conclusion: Development of synchronous and meta-chronous squamous cell carcinomas of the head and neck mucosal sites are in part responsible for failure to improve overall survival rates for patients with squamous cell carcinomas of the head and neck mucosal sites, justifying rigorous follow-up and studies on chemoprevention. J Clin Oncol 19:1358-1362. (C) 2001 by American Society of Clinical Oncology.
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页码:1358 / 1362
页数:5
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