Reduction of Immune Activation with Chloroquine Therapy during Chronic HIV Infection

被引：108

作者：

Murray, Shannon M. ^{[1
]}

Down, Carrie M. ^{[1
]}

Boulware, David R. ^{[2
]}

Stauffer, William M. ^{[2
]}

Cavert, Winston P. ^{[2
]}

Schacker, Timothy W. ^{[2
]}

Brenchley, Jason M. ^{[1
]}

Douek, Daniel C. ^{[1
]}

机构：

[1] NIAID, Human Immunol Sect, NIH, Vaccine Res Ctr, Bethesda, MD 20892 USA

[2] Univ Minnesota, Dept Med, Div Infect Dis & Int Med, Minneapolis, MN 55455 USA

来源：

JOURNAL OF VIROLOGY | 2010年 / 84卷 / 22期

基金：

美国国家卫生研究院;

关键词：

T-CELL-ACTIVATION; LYMPHOCYTE-ACTIVATION; HYDROXYCHLOROQUINE; CD4(+); CD38;

D O I：

10.1128/JVI.01466-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Increased levels of activated T cells are a hallmark of the chronic stage of human immunodeficiency virus (HIV) infection and are highly correlated with HIV disease progression. We evaluated chloroquine (CQ) as a potential therapy to reduce immune activation during HIV infection. We found that the frequency of CD38(+) HLA-DR+ CD8 T cells, as well as Ki-67 expression in CD8 and CD4 T cells, was significantly reduced during CQ treatment. Our data indicate that treatment with CQ reduces systemic T-cell immune activation and, thus, that its use may be beneficial for certain groups of HIV-infected individuals.

引用

页码：12082 / 12086

页数：5

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