Dietary risk factors for testicular carcinoma

Although testicular cancer is a relatively rare lesion, accounting for only 1.1% of all malignant neoplasms in males in Canada, it is the most common cancer among Canadian men 20-45 years of age. Knowledge of the causes of testicular cancer risk in general, and more specifically, its association with diet, remain limited. Data from 601 cases of testicular cancer and 744 population-based controls collected in 8 of the 10 Canadian provinces between 1994-97 were used to explore the relationship between diet and testicular cancer risk. We systematically examined 17 food groups, IS nutrients and 4 individual foods based on data collected through a 69-item food-frequency questionnaire. Our results suggest that high dairy product intake, in particular high intake of cheese (odds ratio [OR] = 1.87; 95% confidence interval [CI] 1.22-2.86; p-trend < 0.001), is associated with an elevated risk of testicular cancer in Canadian males. (C) 2003 Wiley-Liss, Inc.