Resting-State Neural Activity across Face-Selective Cortical Regions Is Behaviorally Relevant

被引:104
作者
Zhu, Qi [1 ]
Zhang, Jiedong [1 ]
Luo, Yu L. L. [1 ]
Dilks, Daniel D. [2 ]
Liu, Jia [1 ,3 ]
机构
[1] Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
[2] MIT, McGovern Inst Brain Res, Cambridge, MA 02144 USA
[3] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
关键词
SURFACE-BASED ANALYSIS; FUNCTIONAL CONNECTIVITY; VISUAL-CORTEX; AREA; FUSIFORM; RECOGNITION; PERCEPTION; NETWORK; PROSOPAGNOSIA; FLUCTUATIONS;
D O I
10.1523/JNEUROSCI.0873-11.2011
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Interest has increased recently in correlations across brain regions in the resting-state fMRI blood oxygen level-dependent (BOLD) response, but little is known about the functional significance of these correlations. Here we directly test the behavioral relevance of the resting-state correlation between two face-selective regions in human brain, the occipital face area (OFA) and the fusiform face area (FFA). We found that the magnitude of the resting-state correlation, henceforth called functional connectivity (FC), between OFA and FFA correlates with an individual's performance on a number of face-processing tasks, not non-face tasks. Further, we found that the behavioral significance of the OFA/FFA FC is independent of the functional activation and the anatomical size of either the OFA or FFA, suggesting that face processing depends not only on the functionality of individual face-selective regions, but also on the synchronized spontaneous neural activity between them. Together, these findings provide strong evidence that the functional correlations in the BOLD response observed at rest reveal functionally significant properties of cortical processing.
引用
收藏
页码:10323 / 10330
页数:8
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