Natural regulatory T cells in autoimmunity

被引：139

作者：

Lourenco, Elaine V. ^{[1
]}

La Cava, Antonio ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA

来源：

AUTOIMMUNITY | 2011年 / 44卷 / 01期

基金：

新加坡国家研究基金会; 美国国家卫生研究院;

关键词：

Tregs; CD4(+)CD25(+)FOXP3(+) T cells; natural Tregs; autoimmunity; GROWTH-FACTOR-BETA; SYSTEMIC-LUPUS-ERYTHEMATOSUS; IMMUNOLOGICAL SELF-TOLERANCE; DENDRITIC CELLS; TGF-BETA; CUTTING EDGE; SUPPRESSOR FUNCTION; HELPER TYPE-1; FUNCTIONAL-CHARACTERIZATION; INTERLEUKIN-10; PRODUCTION;

D O I：

10.3109/08916931003782155

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The suppressive/immunomodulatory function of CD4(+)CD25(+)FOXP3(+) regulatory T (Treg) cells is crucial for the maintenance of immune homeostasis, which helps to prevent autoimmunity and reduce the inflammation induced by pathogens and environmental insults. This review summarizes the current knowledge on the types and mechanisms of action of Treg cells and their role in the immune tolerance to self-antigens, with a particular focus on naturally occurring Treg cells.

引用

页码：33 / 42

页数：10

共 138 条

[1]

Origin of regulatory T cells with known specificity for antigen [J].

Apostolou, I ;

Sarukhan, A ;

Klein, L ;

von Boehmer, H .

NATURE IMMUNOLOGY, 2002, 3 (08) :756-763

[2]

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation [J].

Asseman, C ;

Mauze, S ;

Leach, MW ;

Coffman, RL ;

Powrie, F .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (07) :995-1003

[3]

HIGH-LEVELS OF INTERLEUKIN-10 PRODUCTION IN-VIVO ARE ASSOCIATED WITH TOLERANCE IN SCID PATIENTS TRANSPLANTED WITH HLA MISMATCHED HEMATOPOIETIC STEM-CELLS [J].

BACCHETTA, R ;

BIGLER, M ;

TOURAINE, JL ;

PARKMAN, R ;

TOVO, PA ;

ABRAMS, J ;

MALEFYT, RD ;

DEVRIES, JE ;

RONCAROLO, MG .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (02) :493-502

[4]

CD4+CD25high regulatory cells in human peripheral blood [J].

Baecher-Allan, C ;

Brown, JA ;

Freeman, GJ ;

Hafler, DA .

JOURNAL OF IMMUNOLOGY, 2001, 167 (03) :1245-1253

[5]

In vitro generation of interleukin 10-producing regulatory CD4+ T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines [J].

Barrat, FJ ;

Cua, DJ ;

Boonstra, A ;

Richards, DF ;

Crain, C ;

Savelkoul, HF ;

de Waal-Malefyt, R ;

Coffman, RL ;

Hawrylowicz, CM ;

O'Garra, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :603-616

[6]

Rapamycin promotes expansion of functional CD4+CD25+FOXP3+ regulatory T cells of both healthy subjects and type 1 diabetic patients [J].

Battaglia, Manuela ;

Stabilini, Angela ;

Migliavacca, Barbara ;

Horejs-Hoeck, Jutta ;

Kaupper, Thomas ;

Roncarolo, Maria-Grazia .

JOURNAL OF IMMUNOLOGY, 2006, 177 (12) :8338-8347

[7]

Timed ablation of regulatory CD4+ T cells can prevent murine AIDS progression [J].

Beilharz, MW ;

Sammels, LM ;

Paun, A ;

Shaw, K ;

van Eeden, P ;

Watson, MW ;

Ashdown, ML .

JOURNAL OF IMMUNOLOGY, 2004, 172 (08) :4917-4925

[8]

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 [J].

Bennett, CL ;

Christie, J ;

Ramsdell, F ;

Brunkow, ME ;

Ferguson, PJ ;

Whitesell, L ;

Kelly, TE ;

Saulsbury, FT ;

Chance, PF ;

Ochs, HD .

NATURE GENETICS, 2001, 27 (01) :20-21

[9]

Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4+25+ immunoregulatory T cells [J].

Bensinger, SJ ;

Bandeira, A ;

Jordan, MS ;

Caton, AJ ;

Laufer, TM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (04) :427-438

[10]

Expansion and characteristics of human T regulatory type 1 cells in co-cultures simulating tumor microenvironment [J].

Bergmann, Christoph ;

Strauss, Laura ;

Zeidler, Reinhard ;

Lang, Stephan ;

Whiteside, Theresa L. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2007, 56 (09) :1429-1442

← 1 2 3 4 5 6 7 8 9 10 →