Science and Society - Research ethics and the challenge of whole-genome sequencing

被引：154

作者：

McGuire, Amy L. ^{[2
]}

Caulfield, Timothy ^{[1
]}

Cho, Mildred K. ^{[3
]}

机构：

[1] Univ Alberta, Hlth Law Inst, Edmonton, AB T6G 2H5, Canada

[2] Baylor Coll Med, Ctr Med Eth & Hlth Policy, Houston, TX 77030 USA

[3] Stanford Univ, Stanford Ctr Biomed Eth, Stanford, CA 94305 USA

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 02期

关键词：

GENETIC RESEARCH; FAMILY-MEMBERS; MEDICINE; DUTY;

D O I：

10.1038/nrg2302

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The recent completion of the first two individual whole-genome sequences is a research milestone. As personal genome research advances, investigators and international research bodies must ensure ethical research conduct. We identify three major ethical considerations that have been implicated in whole-genome research: the return of research results to participants; the obligations, if any, that are owed to participants' relatives; and the future use of samples and data taken for whole-genome sequencing. Although the issues are not new, we discuss their implications for personal genomics and provide recommendations for appropriate management in the context of research involving individual whole-genome sequencing.

引用

页码：152 / 156

页数：5