Peripheral cytokine release in Alzheimer patients: correlation with disease severity

被引：66

作者：

Sala, G

Galimberti, G

Canevari, C

Raggi, ME

Isella, V

Facheris, M

Appollonio, I

Ferrarese, C

机构：

[1] Univ Milan, San Gerardo Hosp, Dept Neurol, I-20052 Monza, MI, Italy

[2] Sci Inst E Medea, Bosisio, Parini, Italy

来源：

NEUROBIOLOGY OF AGING | 2003年 / 24卷 / 07期

关键词：

Alzheimer's disease; inflammation; peripheral cytokine release; disease severity;

D O I：

10.1016/S0197-4580(03)00010-1

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Various studies suggested that inflammation is involved in the pathogenesis of Alzheimer's disease (AD). We investigated cytokine release from LPS-stimulated blood cells of 32 AD patients, with different disease severity, compared to 16 age-related controls. A significant decrease of IL-1beta and IL-6 secretion was observed in severely demented patients; TNF-alpha release was also decreased, but not significantly. By contrast, mild and moderate patients showed a cytokine release similar to controls. IL-1beta, IL-6 and TNF-alpha secretion was negatively correlated with the severity of dementia, quantified by the MMSE. Our data suggest that alterations of the immune profile are associated with AD progression. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：909 / 914

页数：6

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