Reversal of learned helplessness by morphine in rats: Involvement of a dopamine mediation

被引:18
作者
Besson, A
Privat, AM
Eschalier, A
Fialip, J
机构
[1] Univ Auvergne, Fac Pharm, Pharmacol Lab, F-63001 Clermont Ferrand 1, France
[2] Univ Auvergne, Fac Med, Lab Pharmacol Med, Equipe NPPUA, F-63001 Clermont Ferrand, France
关键词
learned helplessness; morphine; haloperidol; dopamine; rats;
D O I
10.1016/S0091-3057(98)00002-1
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The aim of this study was to examine the role of dopamine neurotransmission in the effects of morphine in the learned helplessness paradigm in rats, a generally recognized model of depression. In this model, rats first exposed to inescapable shocks (stressed rats) exhibited an escape deficit in a subsequent shuttle-box test performed 48 h later for 3 consecutive days. The numbers of escape failures and intertrial crossings (motor activity during each intertrial interval) were recorded. Morphine was injected twice daily for 5 days (6 mg/kg/day, SC), and haloperidol, a preferential D-2-dopamine receptor antagonist, was injected IP 15 min before each shuttle-box session. At the highest dose tested (150 mu g/kg) haloperidol mimicked the behavioral deficit produced by inescapable shocks. A 37.5 mu g/kg dose of haloperidol, which was ineffective by itself, reversed the morphine-induced improvement of escape behavior in previously stressed rats and the morphine-induced increase in intertrial activity in both stressed and nonstressed animals. These results support roles (a) for a dysregulation of dopaminergic neuronal activity in the expression of escape deficit subsequent to an inescapable aversive situation, and (b) for a dopaminergic mediation in the effects of morphine in the learned helplessness paradigm. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:519 / 525
页数:7
相关论文
共 52 条
[1]   DIFFERENTIAL EFFECT OF STRESS ON INVIVO DOPAMINE RELEASE IN STRIATUM, NUCLEUS ACCUMBENS, AND MEDIAL FRONTAL-CORTEX [J].
ABERCROMBIE, ED ;
KEEFE, KA ;
DIFRISCHIA, DS ;
ZIGMOND, MJ .
JOURNAL OF NEUROCHEMISTRY, 1989, 52 (05) :1655-1658
[2]   ENDOGENOUS OPIOIDS - BIOLOGY AND FUNCTION [J].
AKIL, H ;
WATSON, SJ ;
YOUNG, E ;
LEWIS, ME ;
KHACHATURIAN, H ;
WALKER, JM .
ANNUAL REVIEW OF NEUROSCIENCE, 1984, 7 :223-255
[3]  
*AM PSYCH ASS, 1994, DIAGN STAT MAN MENT, P320
[4]   NORADRENERGIC AND DOPAMINERGIC INTERACTIONS IN ESCAPE BEHAVIOR - ANALYSIS OF UNCONTROLLABLE STRESS EFFECTS [J].
ANISMAN, H ;
RITCH, M ;
SKLAR, LS .
PSYCHOPHARMACOLOGY, 1981, 74 (03) :263-268
[5]   MULTIPLE NEUROCHEMICAL AND BEHAVIORAL CONSEQUENCES OF STRESSORS - IMPLICATIONS FOR DEPRESSION [J].
ANISMAN, H ;
ZACHARKO, RM .
PHARMACOLOGY & THERAPEUTICS, 1990, 46 (01) :119-136
[6]  
BERGER A, 1987, 3RD GENERATION PROGR, P637
[7]   Effects of morphine, naloxone and their interaction in the learned helplessness paradigm in rats [J].
Besson, A ;
Privat, AM ;
Eschalier, A ;
Fialip, J .
PSYCHOPHARMACOLOGY, 1996, 123 (01) :71-78
[8]   STIMULATION OF DOPAMINE D-2 BUT NOT D-1 RECEPTORS REDUCES IMMOBILITY TIME OF RATS IN THE FORCED SWIMMING TEST - IMPLICATION FOR ANTIDEPRESSANT ACTIVITY [J].
BORSINI, F ;
LECCI, A ;
MANCINELLI, A ;
DARANNO, V ;
MELI, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 148 (03) :301-307
[9]  
BRILEY M, 1996, INT CLIN PSYCHOPHARM, V4, P9
[10]   DOPAMINE AND DEPRESSION [J].
BROWN, AS ;
GERSHON, S .
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1993, 91 (2-3) :75-109