D-aspartate modulates melatonin synthesis in rat pinealocytes

被引：81

作者：

Ishio, S

Yamada, H

Hayashi, M

Yatsushiro, S

Noumi, T

Yamaguchi, A

Moriyama, Y ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Osaka 5670047, Japan

[2] Novartis Pharma KK, Takarazuka, Hyogo 6650043, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 249卷 / 2-3期

关键词：

D-aspartate; melatonin; pinealocyte; L-glutamate; regulation; serotonin N-acetyltransferase; cyclic AMP;

D O I：

10.1016/S0304-3940(98)00414-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It has been known that pinealocytes contain the highest level of D-aspartate among various neuroendocrine cells in the rat. Here, we report that exogenous D-aspartate strongly inhibited norepinephrine-dependent melatonin synthesis in the rat pineal gland, the concentration required for 50% inhibition being 75 mu M. This inhibition was due at least partly to decreased norepinephrine-dependent serotonin N-acetyltransferase activity. Upon incubation, D-aspartate was gradually released from pinealocytes and accumulated in the incubation medium as determined by high-performance liquid chromatography on a Pirkle-type chiral column, These results suggest that D-aspartate acts as a negative regulator for melatonin synthesis in the pineal gland. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：143 / 146

页数：4

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