Platinum-catalyzed chemoselectively hydrative dimerization of 2-alkynyl-1-acetylbenzenes for one-pot facile synthesis of chrysene derivatives

被引：43

作者：

Das, Arindam ^{[1
]}

Liao, Hsuan-Hung ^{[1
]}

Liu, Rai-Shung ^{[1
]}

机构：

[1] Natl Tsing Hua Univ, Dept Chem, Hsinchu, Taiwan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 24期

关键词：

D O I：

10.1021/jo701580r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[Graphics] We report one-pot syntheses of chrysene compounds via PtCl2-catalyzed hydrative dimerization of readily available 2-alkynyl-1-acetylbenzenes. This new tandem catalysis comprises an initial selective hydration of the alkyne, followed by chemoselective dimerization of diketone intermediates. The mechanism of this cyclization has been elucidated by C-13 labeling experiments as well as isolation of reaction intermediates.

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页码：9214 / 9218

页数：5

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