Histological co-localization of iron in Aβ plaques of PS/APP transgenic mice

被引：99

作者：

Falangola, MF

Lee, SP

Nixon, RA

Duff, K

Helpern, JA

机构：

[1] Nathan S Kline Inst Psychiat Res, Ctr Adv Brain Imaging, Orangeburg, NY 10962 USA

[2] Nathan S Kline Inst Psychiat Res, Ctr Dementia Res, Orangeburg, NY 10962 USA

[3] NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA

[4] NYU, Sch Med, Dept Physiol & Neurosci, New York, NY 10016 USA

[5] NYU, Sch Med, Dept Radiol, New York, NY 10016 USA

来源：

NEUROCHEMICAL RESEARCH | 2005年 / 30卷 / 02期

关键词：

beta-amyloid; Alzheimers disease; brain; iron; MRI; transgenic mice;

D O I：

10.1007/s11064-004-2442-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study confirms the presence of iron, co-localized with A beta plaques, in PS/APP mouse brain, using Per1s' stain for Fe3+ supplemented by 3,3'-diaminobenzidine (DAB) and A beta immunohistochemistry in histological brains sections fixed with formalin or methacarn. In this study, the fixation process and the slice thickness did not interfere with the Perls' technique. The presence of iron in beta-amyloid plaques in PS/APP transgenic mice, a model of Alzheimer's disease (AD) pathology, may explain previous reports of reductions of transverse relaxation time (T-2) in MRI studies and represent the source of the intrinsic A beta plaque MR contrast in this model.

引用

页码：201 / 205

页数：5

共 30 条

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