Direct detection of multidrug-resistant mycobacterium tuberculosis in clinical specimens in low- and high-incidence countries by line probe assay

被引：40

作者：

Johansen, IS

Lundgren, B

Sosnovskaja, A

Thomsen, VO

机构：

[1] Statens Serum Inst, Int Reference Lab Mycobacteriol, DK-2300 Copenhagen, Denmark

[2] Hvidovre Univ Hosp, Dept Clin Microbiol, Copenhagen, Denmark

[3] Natl TB Reference Lab, Vilnius, Lithuania

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2003年 / 41卷 / 09期

关键词：

D O I：

10.1128/JCM.41.9.4454-4456.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The INNO-LiPA Rif.TB assay is designed for the detection of rpoB gene mutations causing rifampin resistance in isolates. We applied the method directly to 60 Lithuanian and Danish clinical specimens to detect rifampin resistance rapidly. Results were obtained in 78.3% of clinical specimens, and all were concordant with those obtained by BACTEC 460. The assay could have major impact on the management of multidrug-resistant tuberculosis.

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页码：4454 / 4456

页数：3

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