Effects of cardiorespiratory fitness and cerebral blood flow on cognitive outcomes in older women

被引:150
作者
Brown, Allison D. [1 ]
McMorris, Carly A. [2 ]
Longman, R. Stewart [3 ,4 ]
Leigh, Richard [1 ,6 ]
Hill, Michael D. [4 ,5 ,6 ,7 ]
Friedenreich, Christine M. [8 ]
Poulin, Marc J. [1 ,4 ,5 ,9 ,10 ]
机构
[1] Univ Calgary, Fac Med, Dept Physiol & Biophys, Calgary, AB T2N 4N1, Canada
[2] Univ Calgary, Dept Psychol, Calgary, AB T2N 4N1, Canada
[3] Calgary Hlth Reg, Dept Psychol, Calgary, AB T2N 2T9, Canada
[4] Univ Calgary, Fac Med, Hotchkiss Brain Inst, Calgary, AB T2N 4N1, Canada
[5] Univ Calgary, Fac Med, Dept Clin Neurosci, Calgary, AB T2N 2T9, Canada
[6] Univ Calgary, Fac Med, Dept Med, Calgary, AB T2N 4N1, Canada
[7] Univ Calgary, Dept Community Hlth Sci, Calgary, AB T2N 4N1, Canada
[8] Alberta Canc Board, Div Populat Hlth, Calgary, AB T2N 4N2, Canada
[9] Univ Calgary, Fac Kinesiol, Calgary, AB T2N 1N4, Canada
[10] Univ Calgary, Fac Med, Libin Cardiovasc Inst Alberta, Calgary, AB T2N 4N1, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
Cerebrovascular circulation; Women; Hypertension; Transcranial Doppler ultrasound; Aging; Exercise; Cognitive function; PHYSICAL-ACTIVITY QUESTIONNAIRE; POLYCYSTIC-OVARY-SYNDROME; MAXIMAL AEROBIC CAPACITY; EARLY ALZHEIMER-DISEASE; WHITE-MATTER LESIONS; END-TIDAL PCO2; TRANSCRANIAL DOPPLER; FREE TESTOSTERONE; RISK-FACTORS; AGING BRAIN;
D O I
10.1016/j.neurobiolaging.2008.11.002
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The mechanisms by which aerobic fitness confers beneficial effects on cognition with aging are unclear but may involve cerebrovascular adaptations. In a cross-sectional study of women from the community (n = 42; age range = 50-90 years), we sought to determine whether physical fitness is associated with higher cerebrovascular function, and its relationship to cognition. Main outcome measures included resting cerebral blood flow, cerebrovascular reserve, physical fitness (i.e., (V) over dotO(2)max) and cognition. Physically fit women had lower resting mean arterial pressure (MAP) and higher cerebrovascular conductance (CVC) than sedentary women. Overall cognition was negatively correlated with age and positively correlated with (V) over dotO(2)max. (V) over dotO(2)max was a predictor of resting CVC and MAP, and CVC and MAP when end-tidal gases were held constant at near-resting values. MAP and CVC were predictors of cognition. This study identified strong associations between physical fitness, vascular function and cognition, and provides new understanding regarding the mechanisms by which fitness positively impacts cognition with aging. The implications of this research are considerable and warrant future investigation. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:2047 / 2057
页数:11
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