Transplantation of glial cell line-derived neurotrophic factor-expressing cells into the striatum and nucleus accumbens attenuates acquisition of cocaine self-administration in rats

被引:39
作者
Green-Sadan, T [1 ]
Kinor, N [1 ]
Roth-Deri, I [1 ]
Geffen-Aricha, R [1 ]
Schindler, CJ [1 ]
Yadid, G [1 ]
机构
[1] Bar Ilan Univ, Fac Life Sci, IL-52900 Ramat Gan, Israel
关键词
astrocytes; neurotrophic factors; plasticity; simian virus-40 glia (SVG) cells;
D O I
10.1046/j.1460-9568.2003.02943.x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neurotrophic factors, such as glial cell line-derived neurotrophic factor (GDNF), may play a role in drug-induced biochemical and behavioural adaptations that characterize addiction. We found that GDNF mRNA levels are lower in the striatum of rats that chronically self-administered cocaine. Therefore, we examined the effect of transplanted cells used as a biodelivery system for GDNF on cocaine self-administration in rats. A human astrocyte-like cell line, which produces and excretes GDNF, was transplanted into the striatum and nucleus accumbens of rats. These rats showed a significantly lower number of active lever presses in the cocaine self-administration paradigm compared with control rats. Moreover, rats that received a chronic infusion of GDNF via a micro-osmotic pump also exhibited weak cocaine self-administration. Therefore, we conclude that exogenous augmentation of GDNF repositories may be useful in suppressing cocaine self-administration.
引用
收藏
页码:2093 / 2098
页数:6
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