Effects of lignans extracted from Eucommia ulmoides and aldose reductase inhibitor epalrestat on hypertensive vascular remodeling

被引：37

作者：

Gu, Juan ^{[1
]}

Wang, Jun-Jie ^{[1
,2
]}

Yan, Jin ^{[3
]}

Cui, Chang-Fu ^{[4
]}

Wu, Wei-Hua ^{[1
,5
]}

Li, Ling ^{[1
]}

Wang, Zhen-Shan ^{[1
]}

Yu, Min ^{[1
]}

Gao, Na ^{[1
]}

Liu, Li ^{[1
]}

Ouyang, Dong-Sheng ^{[1
]}

机构：

[1] Cent S Univ, Inst Clin Pharmacol, Changsha 410078, Hunan, Peoples R China

[2] Xiangnan Univ, Dept Pharmacol, Chenzhou 423000, Hunan, Peoples R China

[3] Cent S Univ, Dept Nursing, Affiliated Teaching Hosp 3, Changsha 410013, Hunan, Peoples R China

[4] 521 Hosp, Res Inst China Weap Ind, Xian 710065, Shanxi, Peoples R China

[5] Huaihua Med Coll, Huaihua 418000, Peoples R China

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2011年 / 133卷 / 01期

基金：

美国国家科学基金会;

关键词：

Aldose reductase; Eucommia ulmoides; Lignans; Epalrestat; Captopril; Hypertension; Vascular remodeling; SMOOTH-MUSCLE-CELLS; NAD(P)H OXIDASE; OXIDATIVE STRESS; EXPRESSION; INVOLVEMENT; ACTIVATION; MEDIATORS; THERAPY; RELEASE; RATS;

D O I：

10.1016/j.jep.2010.08.055

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Aim oft-he study: To investigate the effects of lignans extracted from Eucommia ulmoides and epalrestat on vascular remodeling in spontaneously hypertensive rats. Materials and methods: Ten-week-old male spontaneously hypertensive rats were randomly divided into 3 groups (12 rats each group), and treated orally with 100 mg/kg/d of captopril (an angiotensin-converting enzyme inhibitor), 100 mg/kg/d of epalrestat (an aldose reductase inhibitor) and 300 mg/kg/d of lignans by gavage daily for 16 weeks, respectively. Sex-, age-, and number-matched spontaneously hypertensive rats and normotensive Wistar Kyoto rats, were treated with distilled water (vehicle) as controls. The rats were weighed weekly. Mean arterial blood pressure and heart rate were measured periodically by non-invasive blood pressure monitoring. They were sacrificed at the end of experiment (26-week-old). Superior mesenteric artery and aorta were isolated for determination of histomorphometry and the expression of aldose reductase by immunohistochemistry. Results: Captopril and lignans, but not epalrestat, decreased mean arterial blood pressure in spontaneously hypertensive rats. Vascular remodeling was improved in all three treated groups by histomorphometry. Conclusions: Both lignans and epalrestat reversed hypertensive vascular remodeling. Aldose reductase played a vital role in the pathologic process of hypertensive vascular remodeling rather than elevation of blood pressure. These data suggested that aldose reductase could be a new therapeutic target for the treatment of cardiovascular diseases. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：6 / 13

页数：8

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